Friday K E, Childs M T, Tsunehara C H, Fujimoto W Y, Bierman E L, Ensinck J W
Department of Medicine, University of Washington, Seattle.
Diabetes Care. 1989 Apr;12(4):276-81. doi: 10.2337/diacare.12.4.276.
We studied the effect of omega-3 fatty acids (omega 3FA) on glucose homeostasis and lipoprotein levels in eight type II (non-insulin-dependent)-diabetic subjects ingesting 8 g/day omega 3FA for 8 wk as marine-lipid concentrate capsules. After omega 3FA supplementation, fasting plasma glucose levels increased 22% (P = .005) and meal-stimulated glucose increased 35% (P = .036). The percentage of glucose elevation correlated with percentage ideal body weight (r = .73, P = .04). No significant changes were seen in fasting or meal-stimulated plasma insulin, glucose disposal, or insulin-to-glucagon ratios. Very-low-density lipoprotein cholesterol and triglyceride (TG) levels showed consistent reductions of 56% (P less than .001) and 42% (P less than .001), respectively, after omega 3FA supplementation. Total cholesterol levels decreased 7% (P less than .05) without alteration in low- or high-density lipoprotein cholesterol. Thus, omega 3FA supplementation at a dose of 8 g/day significantly improves plasma TG levels but increases fasting and meal-stimulated glucose concentrations in the type II diabetic patient not treated with insulin or sulfonylurea agents. Marine-lipid concentrate capsules supplying large amounts of omega 3FAs should be used cautiously in the type II diabetic patient.
我们研究了ω-3脂肪酸（ω-3FA）对8名II型（非胰岛素依赖型）糖尿病患者葡萄糖稳态和脂蛋白水平的影响。这些患者每天服用8克ω-3FA，以海洋脂质浓缩胶囊形式服用8周。补充ω-3FA后，空腹血糖水平升高22%（P = .005），餐后刺激血糖升高35%（P = .036）。血糖升高百分比与理想体重百分比相关（r = .73，P = .04）。空腹或餐后刺激的血浆胰岛素、葡萄糖处置或胰岛素与胰高血糖素比值未见显著变化。补充ω-3FA后，极低密度脂蛋白胆固醇和甘油三酯（TG）水平分别持续降低56%（P < .001）和42%（P < .001）。总胆固醇水平降低7%（P < .05），低密度或高密度脂蛋白胆固醇无变化。因此，对于未接受胰岛素或磺脲类药物治疗的II型糖尿病患者，每天补充8克ω-3FA可显著改善血浆TG水平，但会增加空腹和餐后刺激的葡萄糖浓度。在II型糖尿病患者中应谨慎使用提供大量ω-3FA的海洋脂质浓缩胶囊。
