Ito H, Masuda H, Tahara E, Wittekind C
Section of Clinical Pathology, Kure Kyousai Hospital, Japan.
Dtsch Med Wochenschr. 1989 Apr 21;114(16):623-7. doi: 10.1055/s-2008-1066646.
Multiple primary hepatic carcinoid tumours of the liver was a chance finding at autopsy of an 81-year-old woman. There had been no signs of this or any other paraneoplastic syndrome in life. The tumour had a characteristic solid-alveolar structure (type A of Soga) with only a few atypical cells. Neuron-specific enolase and chromogranin were demonstrated immunohistologically in almost all tumour cells, but S-100 protein, human choriogonadotropin and serotonin in only a few. Peptides and alpha-fetoprotein, however, could not be demonstrated in the tumours. Electronmicroscopy revealed secretory granules of variable size and density in the cytoplasm of the tumour cells.
多发性原发性肝类癌肿瘤是在一位81岁女性尸检时偶然发现的。生前没有该肿瘤或任何其他副肿瘤综合征的迹象。肿瘤具有特征性的实性-肺泡结构（索加A型），仅有少数非典型细胞。免疫组织化学显示，几乎所有肿瘤细胞中都有神经元特异性烯醇化酶和嗜铬粒蛋白，但只有少数细胞中有S-100蛋白、人绒毛膜促性腺激素和血清素。然而，肿瘤中未检测到肽和甲胎蛋白。电子显微镜显示肿瘤细胞质中有大小和密度各异的分泌颗粒。
