Cinkaya Ahmet, Akin Mustafa, Sengul Adem
Department of Radiation Oncology, Balikesir Public Hospital, Balikesir, Turkey.
J Cancer Res Ther. 2016 Jan-Mar;12(1):150-4. doi: 10.4103/0973-1482.154000.
Breast cancer is the most common cancer in women. Treatment responses are variable depending on tumor morphological characteristics, clinical characteristics, and hormonal receptor levels. In current medical practice, estrogen receptor (ER), progesterone receptor (PGR), and human epidermal growth factor receptor 2 (HER2) levels have been identified as important prognostic factors; they can change prognosis and treatment modalities. In this study, the prognostic factors of patients with triple-negative breast cancer (TNBC) were examined retrospectively.
Some 110 cases with negative prognostic and predictive proteins (ER, PGR, and HER2) were included in this study. Median follow-up was 56 months. Recurrences, overall survival, and prognostic factors were evaluated.
We revealed in our triple-negative series that nodal status, tumor size, whole breast radiation doses, and type of surgery are the most useful prognostic markers.
Triple-negative breast cancers, especially basal-like subtypes, have bad prognoses. They have high histopathological grades and high risk of invasion. This group can make early metastases and expected survival is usually short. We need to focus on new treatment strategy modalities on this group, and pretreatment values of different prognostic markers are well-identified, such as androgen receptors, basal cytokeratin expression, and BRCA gene status.
乳腺癌是女性最常见的癌症。治疗反应因肿瘤形态特征、临床特征和激素受体水平而异。在当前医疗实践中，雌激素受体（ER）、孕激素受体（PGR）和人表皮生长因子受体2（HER2）水平已被确定为重要的预后因素；它们可改变预后和治疗方式。本研究回顾性分析三阴性乳腺癌（TNBC）患者的预后因素。
本研究纳入了110例预后和预测蛋白（ER、PGR和HER2）均为阴性的病例。中位随访时间为56个月。评估复发情况、总生存率和预后因素。
我们在三阴性病例系列中发现，淋巴结状态、肿瘤大小、全乳放疗剂量和手术类型是最有用的预后标志物。
三阴性乳腺癌，尤其是基底样亚型，预后较差。它们具有高组织病理学分级和高侵袭风险。该组患者易早期发生转移，预期生存时间通常较短。我们需要关注针对该组患者的新治疗策略模式，并且不同预后标志物的预处理价值已得到明确，如雄激素受体、基底细胞角蛋白表达和BRCA基因状态。
