The Relationship of Mutation Carriage of and Family History in Triple-Negative Breast Cancer: Experience from a Diagnostic Center in Turkey.

OBJECTIVE

genes play a role in the etiopathogenesis of 10%-30% of triple-negative breast cancer (TNBC). This study aims to investigate the genes and the demographic and clinicopathological features in patients with TNBC. The study also examined the impact of cancer history of TNBC individuals' relatives on the risk of mutation carriership rate.

MATERIALS AND METHODS

The genes of 65 women diagnosed with TNBC between 2011 and 2017 were investigated using next-generation sequencing. We analyzed the correlations of patients' demographic and clinicopathologic parameters and family history with mutation status. We used the χ-test, t-test, Mann-Whitney U test, and logistic regression statistical methods.

RESULTS

The mutation carrier rate was 16.9%. Patients who had mutations were compared with those who did not in terms of demographic and clinicopathological parameters. In the mutation carrier group, the Ki-67 index and the number of relatives with cancer were higher than the non-carrier group. Logistic regression analysis revealed that when the number of relatives with breast or ovarian cancer was ≥2, the risk of carrying the mutation increased by 15-fold. Regardless of the type of cancer (including cancers in other organs besides breast or ovary), the risk of carrying the mutation increased 1.3 times with each increase in the number of relatives with cancer for the patient with TNBC.

CONCLUSION

In cases with a diagnosis of TNBC, a significant relationship exists between the number of relatives with cancer in the family history and the risk of carrying mutations in the genes. This relationship can be confirmed further by large-scale studies with more cases.