铁催化的未活化醛与简单烯烃的区域选择性转移氢化偶联反应。
Iron-Catalyzed Regioselective Transfer Hydrogenative Couplings of Unactivated Aldehydes with Simple Alkenes.
机构信息
State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China.
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, 300071, China.
出版信息
Angew Chem Int Ed Engl. 2016 May 17;55(21):6315-8. doi: 10.1002/anie.201602130. Epub 2016 Apr 13.
An FeBr3 -catalyzed reductive coupling of various aldehydes with alkenes that proceeds through a direct hydride transfer pathway has been developed. With (i) PrOH as the hydrogen donor under mild conditions, previously challenging coupling reactions of unactivated alkyl and aryl aldehydes with simple alkenes, such as styrene derivatives and α-olefins, proceeded smoothly to furnish a diverse range of functionalized alcohols with complete linear regioselectivity.
一种通过直接氢转移途径进行的各种醛与烯烃的 FeBr3 催化还原偶联反应已经被开发出来。在（i）PrOH 作为氢供体的温和条件下，以前具有挑战性的未活化的烷基和芳基醛与简单烯烃（如苯乙烯衍生物和α-烯烃）的偶联反应能够顺利进行，以提供具有完全线性区域选择性的各种官能化醇。
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