Nguyen Khoa D, Park Boyoung Y, Luong Tom, Sato Hiroki, Garza Victoria J, Krische Michael J
Department of Chemistry, University of Texas at Austin, Austin, TX 78712, USA.
Science. 2016 Oct 21;354(6310). doi: 10.1126/science.aah5133.
α-Olefins are the most abundant petrochemical feedstock beyond alkanes, yet their use in commodity chemical manufacture is largely focused on polymerization and hydroformylation. The development of byproduct-free catalytic C-C bond-forming reactions that convert olefins to value-added products remains an important objective. Here, we review catalytic intermolecular reductive couplings of unactivated and activated olefin-derived nucleophiles with carbonyl partners. These processes represent an alternative to the longstanding use of stoichiometric organometallic reagents in carbonyl addition.
α-烯烃是仅次于烷烃的最丰富的石化原料,然而它们在商品化学品制造中的应用主要集中在聚合反应和氢甲酰化反应上。开发将烯烃转化为增值产品的无副产物催化C-C键形成反应仍然是一个重要目标。在这里,我们综述了未活化和活化的烯烃衍生亲核试剂与羰基化合物之间的催化分子间还原偶联反应。这些过程是在羰基加成反应中长期使用化学计量有机金属试剂的一种替代方法。