Piccirilli M, D'Alessandro P, Finali G, Piccinin G L, Agostini L
Clinica Neurologica dell'Università degli Studi, Perugia, Italy.
Eur Neurol. 1989;29(2):71-6. doi: 10.1159/000116381.
The purpose of this longitudinal study was to investigate if the presence of frontal motor deficits in parkinsonians without signs of global intellectual impairment may have a predictive value for the development of a progressive dementing process during the course of the illness. An examination of the higher level of motor organization, using skills thought to depend upon the integrity of the frontal regions, was performed by 30 parkinsonian patients who did not present any signs of general intellectual impairment. According to their performance, as compared with controls, they were divided into two subgroups: those with and those without frontal dysfunctions. After a mean period of 4 years, a second neuropsychological examination was carried out to assess any eventual change of mental status. The results suggest that frontal dysfunctions may be observed several years before the appearance of generalized intellectual impairment and may be considered one of the predictive factors for development of dementia in Parkinson's disease. Careful consideration of these defects during examination of motor abilities may be of value in the clinical management of parkinsonian patients.
这项纵向研究的目的是调查在没有整体智力损害迹象的帕金森病患者中，额叶运动功能障碍的存在是否对疾病过程中进行性痴呆过程的发展具有预测价值。30名没有任何一般智力损害迹象的帕金森病患者接受了一项对高级运动组织的检查，该检查使用了被认为依赖于额叶区域完整性的技能。根据他们与对照组相比的表现，他们被分为两个亚组：有额叶功能障碍的和没有额叶功能障碍的。平均4年后，进行了第二次神经心理学检查以评估心理状态的任何最终变化。结果表明，额叶功能障碍可能在广泛性智力损害出现前数年就可观察到，并且可被视为帕金森病痴呆发展的预测因素之一。在检查运动能力时仔细考虑这些缺陷可能对帕金森病患者的临床管理有价值。
