Monfett Michael, Harrison Julian, Boachie-Adjei Kwadwo, Lutz Gregory
Department of Physiatry, Hospital for Special Surgery, 429 E 75th Street, 3rd Floor, New York, NY, 10021, USA.
Int Orthop. 2016 Jun;40(6):1321-8. doi: 10.1007/s00264-016-3178-3. Epub 2016 Apr 12.
The aim of this article is to provide an overview of clinical and translational research on intradiscal platelet-rich plasma (PRP) as a minimally invasive treatment for discogenic low back pain.
A literature review of in vitro, in vivo, and clinical studies was performed.
There is strong in vitro evidence that supports the use of intradiscal PRP for discogenic low back pain. There are also promising findings in select preclinical animal studies. A clinical study of 29 participants who underwent intradiscal PRP injections for discogenic low back pain found statistically and clinically significant improvements in pain and function through two years of follow-up.
Intradiscal PRP is a safe and a possibly effective treatment for discogenic low back pain. Future studies are warranted to determine the best candidates for this treatment, what the optimal injectate is and what relationships exist between patient-reported outcomes and radiological findings.
本文旨在概述椎间盘内注射富血小板血浆（PRP）作为治疗椎间盘源性下腰痛的微创治疗方法的临床及转化研究。
对体外、体内及临床研究进行文献综述。
有强有力的体外证据支持椎间盘内注射PRP治疗椎间盘源性下腰痛。在一些临床前动物研究中也有令人鼓舞的发现。一项针对29名因椎间盘源性下腰痛接受椎间盘内PRP注射的参与者的临床研究发现，经过两年随访，疼痛和功能在统计学和临床上均有显著改善。
椎间盘内注射PRP是治疗椎间盘源性下腰痛的一种安全且可能有效的方法。未来有必要开展研究以确定该治疗的最佳适用人群、最佳注射剂是什么，以及患者报告的结果与影像学检查结果之间存在何种关系。
