Wang Jing, Li Feng-Sen, Pang Nan-Nan, Tian Ge, Jiang Min, Zhang Hong-Ping, Ding Jian-Bing
Xinjiang National Clinical Research Base of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830000, China; College of Basic Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
Xinjiang National Clinical Research Base of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830000, China.
Evid Based Complement Alternat Med. 2016;2016:5769897. doi: 10.1155/2016/5769897. Epub 2016 Mar 17.
Asthma is a chronic lung inflammation which affects many people. As current therapies for asthma mainly rely on administration of glucocorticoids and have many side effects, new therapy is needed. In this study, we investigated Nepeta bracteata Benth., a traditional Uygur Herb, for its therapeutics effect in OVA induced asthmatic mice model. Treatment of OVA sensitized asthma mice with extract from Nepeta bracteata Benth. demonstrated improved lung pathology, as well as reduced infiltration of eosinophil and neutrophil. Nepeta bracteata Benth. extract also contributed to the rebalance of Th17/Treg cell via decreasing the Th17 cell and increasing the Treg, which was corresponding with the inhibited Th17 cytokine response and increased IL-10 level. Moreover, the reduced TGF-β level and Smad2/3 protein level also suggested that Nepeta bracteata Benth. extract could inhibit TGF-β mediated airway remodelling as well. Taken together, these data suggested that Nepeta bracteata Benth. may be a novel candidate for future antiasthma drug development.
哮喘是一种影响众多人群的慢性肺部炎症。由于目前的哮喘治疗主要依赖糖皮质激素给药且有许多副作用，因此需要新的治疗方法。在本研究中，我们研究了维吾尔族传统草药荆芥（Nepeta bracteata Benth.）对卵清蛋白（OVA）诱导的哮喘小鼠模型的治疗效果。用荆芥提取物治疗OVA致敏的哮喘小鼠，可改善肺部病理状况，并减少嗜酸性粒细胞和中性粒细胞的浸润。荆芥提取物还通过减少Th17细胞并增加调节性T细胞（Treg），促进Th17/Treg细胞的重新平衡，这与Th17细胞因子反应受到抑制和白细胞介素-10（IL-10）水平升高相对应。此外，降低的转化生长因子-β（TGF-β）水平和Smad2/3蛋白水平也表明荆芥提取物也可抑制TGF-β介导的气道重塑。综上所述，这些数据表明荆芥可能是未来抗哮喘药物开发的新候选药物。
