Chang Yu-Sung, Su Hsin-Hao, Ho Szu-Pei
Department of Otolaryngology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, R.O.C.
Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, R.O.C.
Oncol Lett. 2016 Apr;11(4):2668-2672. doi: 10.3892/ol.2016.4262. Epub 2016 Feb 23.
The current study describes a case of adenosquamous carcinoma originating from a thyroglossal duct cyst (TGDC). A 77-year-old man presented with an asymptomatic mass in the left mid-neck, which was soft and mobile on palpation. Fine-needle aspiration was performed, but cytology did not detect any malignant cells. Computed tomography demonstrated a single cystic lesion in the left lobe of the thyroid gland; therefore, surgery was performed on the suspected thyroid cyst. However, it was identified intraoperatively that the lesion was separated from the thyroid gland and instead adhered to an additional hyoid bone; therefore, the Sistrunk procedure was performed. Histopathological examination of the resected tumor confirmed the diagnosis of adenosquamous carcinoma originating from a TGDC. Carcinoma arising from a TGDC is rare, and accounts for 1% of all TGDC cases. The most common subtype of carcinoma associated with TGDC is papillary carcinoma, whilst adenosquamous carcinoma developing from a TGDC is extremely rare, with only one case currently reported in the literature. Although a consensus for the management of this disease has not yet been established, adequate surgical excision with long-term follow-up is currently the preferred treatment.
本研究描述了一例起源于甲状舌管囊肿（TGDC）的腺鳞癌病例。一名77岁男性，左颈部中部出现无症状肿块，触诊时质地柔软且可活动。进行了细针穿刺抽吸，但细胞学检查未发现任何恶性细胞。计算机断层扫描显示甲状腺左叶有一个单一的囊性病变；因此，对疑似甲状腺囊肿进行了手术。然而，术中发现该病变与甲状腺分离，而是附着于一块额外的舌骨；因此，进行了Sistrunk手术。对切除肿瘤的组织病理学检查证实了起源于TGDC的腺鳞癌的诊断。起源于TGDC的癌很罕见，占所有TGDC病例的1%。与TGDC相关的最常见癌亚型是乳头状癌，而起源于TGDC的腺鳞癌极为罕见，目前文献中仅报道了一例。尽管尚未就该疾病的治疗达成共识，但目前首选的治疗方法是进行充分的手术切除并长期随访。
