Huang Qi, Shen Yi, Wang Allen Y, Qiu Shijie, Li Qun, Wang Jian, Wu Zhenhua
Department of Otolaryngology, Head and Neck Surgery, Ningbo Medical Centre Lihuili Eastern Hospital, Ningbo, China.
Ear Sciences Centre, School of Surgery, The University of Western Australia, Perth, WA, Australia.
SAGE Open Med Case Rep. 2018 Mar 29;6:2050313X18767050. doi: 10.1177/2050313X18767050. eCollection 2018.
Squamous cell carcinoma in a thyroglossal duct cyst is exceedingly rare with only 26 reported cases in the literature so far, which only account for 6% of the patients.
We report a unique case of squamous cell carcinoma arising from a thyroglossal duct cyst in a 49-year-old male who was primarily diagnosed as a thyroglossal duct cyst with inflammation. The patient underwent Sistrunk procedure with wide local excision and radiation therapy as well as chemotherapy post-operatively and had no evidence of recurrence or metastasis for 24 months. In addition, we reviewed the relevant literatures.
Whether squamous cell carcinoma actually arises from thyroglossal duct cyst is still controversial; however, carcinoma originating from metaplasia of columnar and squamous epithelium in thyroglossal duct cyst has been well accepted. The gold-standard diagnostic method is fine needle aspiration biopsy with ultrasound guidance. Sistrunk procedure alone or with wide excision is likely to be beneficial. Neck dissection is necessary in patients with positive cervical lymphadenopathy. Radiation therapy and chemotherapy have not yet been clearly defined.
Squamous cell carcinoma arising from thyroglossal duct cyst is really a rare disease, whose origin, treatments and prognosis still remain uncertain. These are solely based on case reports, case series and expert opinions. Hence, more investigations about squamous cell carcinoma will be conducted in the near future.
甲状舌管囊肿中的鳞状细胞癌极为罕见，迄今为止文献中仅报道了26例，仅占患者的6%。
我们报告了一例独特的病例，一名49岁男性甲状舌管囊肿发生鳞状细胞癌，该患者最初被诊断为伴有炎症的甲状舌管囊肿。患者接受了Sistrunk手术，术中进行了广泛局部切除，术后接受了放疗和化疗，24个月内无复发或转移迹象。此外，我们回顾了相关文献。
鳞状细胞癌是否真的起源于甲状舌管囊肿仍存在争议；然而，起源于甲状舌管囊肿柱状和鳞状上皮化生的癌已被广泛接受。金标准诊断方法是超声引导下细针穿刺活检。单独进行Sistrunk手术或联合广泛切除可能有益。颈部淋巴结肿大阳性的患者需要进行颈部清扫术。放疗和化疗尚未明确界定。
甲状舌管囊肿引起的鳞状细胞癌确实是一种罕见疾病，其起源、治疗和预后仍然不确定。这些仅基于病例报告、病例系列和专家意见。因此，近期将对鳞状细胞癌进行更多研究。
