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Impairment of FOXM1 expression in mesenchymal cells from patients with myeloid neoplasms, de novo and therapy-related, may compromise their ability to support hematopoiesis.骨髓增生性肿瘤（新发性和治疗相关性）患者间充质细胞中 FOXM1 表达的损伤可能会损害其支持造血的能力。
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本文引用的文献

1
Polo-like kinase 1-mediated phosphorylation of Forkhead box protein M1b antagonizes its SUMOylation and facilitates its mitotic function.Polo样激酶1介导的叉头框蛋白M1b磷酸化拮抗其SUMO化并促进其有丝分裂功能。
J Biol Chem. 2015 Feb 6;290(6):3708-19. doi: 10.1074/jbc.M114.634386. Epub 2014 Dec 22.
2
Overexpression of forkhead box protein M1 (FOXM1) in ovarian cancer correlates with poor patient survival and contributes to paclitaxel resistance.叉头框蛋白M1（FOXM1）在卵巢癌中的过表达与患者生存率低相关，并导致对紫杉醇耐药。
PLoS One. 2014 Nov 20;9(11):e113478. doi: 10.1371/journal.pone.0113478. eCollection 2014.
3
Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition.通过新型小分子抑制作用抑制FOXM1转录程序。
Nat Commun. 2014 Nov 12;5:5165. doi: 10.1038/ncomms6165.
4
Heterogeneity and renal mass biopsy: a review of its role and reliability.异质性和肾组织活检：对其作用和可靠性的综述。
Cancer Biol Med. 2014 Sep;11(3):162-72. doi: 10.7497/j.issn.2095-3941.2014.03.002.
5
Overexpression of FOXM1 is associated with metastases of nasopharyngeal carcinoma.FOXM1的过表达与鼻咽癌转移相关。
Ups J Med Sci. 2014 Nov;119(4):324-32. doi: 10.3109/03009734.2014.960053. Epub 2014 Sep 18.
6
miR-342-3p suppresses proliferation, migration and invasion by targeting FOXM1 in human cervical cancer.miR-342-3p通过靶向FOXM1抑制人宫颈癌的增殖、迁移和侵袭。
FEBS Lett. 2014 Aug 25;588(17):3298-307. doi: 10.1016/j.febslet.2014.07.020. Epub 2014 Jul 24.
7
USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via β-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.USP22通过β-连环蛋白核定位上调FoxM1表达来促进G1/S期转变，并且与II期胰腺导管腺癌的不良预后相关。
Int J Oncol. 2014 Oct;45(4):1594-608. doi: 10.3892/ijo.2014.2531. Epub 2014 Jul 3.
8
High-risk human papillomavirus infection in different histological subtypes of renal cell carcinoma.不同组织学亚型肾细胞癌中的高危型人乳头瘤病毒感染。
J Med Virol. 2014 Jul;86(7):1134-44. doi: 10.1002/jmv.23945. Epub 2014 Apr 2.
9
SUMOylation inhibits FOXM1 activity and delays mitotic transition.小泛素样修饰抑制叉头框蛋白M1活性并延迟有丝分裂转变。
Oncogene. 2014 Aug 21;33(34):4316-29. doi: 10.1038/onc.2013.546. Epub 2013 Dec 23.
10
NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpoint.NFBD1/MDC1 由 PLK1 磷酸化，并通过调节 TOPOIIα 介导的解连环检查点来控制 G2/M 期转换。
PLoS One. 2013 Dec 11;8(12):e82744. doi: 10.1371/journal.pone.0082744. eCollection 2013.

叉头框蛋白M1（FOXM1）参与肾癌细胞中由Polo样激酶1（PLK1）调控的细胞周期进程。

FOXM1 participates in PLK1-regulated cell cycle progression in renal cell cancer cells.

作者信息

Zhang Zhe, Zhang Guojun, Kong Chuize

机构信息

Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.

Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, P.R. China.

出版信息

Oncol Lett. 2016 Apr;11(4):2685-2691. doi: 10.3892/ol.2016.4228. Epub 2016 Feb 15.

DOI:10.3892/ol.2016.4228
PMID:27073539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4812172/
Abstract

The regulation of entry into and progression through mitosis is important for cell proliferation. Polo-like kinase 1 (PLK1) is involved in multiple stages of mitosis. Forkhead box protein M1 (FOXM1) has multiple functions in tumorigenesis and, in elevated levels, is frequently associated with cancer progression. The present study reports that FOXM1, a substrate of PLK1, controls the transcription mechanism that mediates the PLK1-dependent regulation of the cell cycle. The present study investigated the expression of PLK1 and FOXM1 in the clear renal cell carcinoma 769-P and ACHN cell lines, and indicated that the expression of PLK1 and FOXM1 are correlated in human renal cell cancer cell lines and that the suppression of PLK1 may decrease the expression of FOXM1. The knockdown of FOXM1 or PLK1 in renal cell cancer cell lines caused cell cycle progression to be blocked. As a result, the present study indicated the involvement of FOXM1 in PLK1-regulated cell cycle progression.

摘要

有丝分裂的进入和进程调控对细胞增殖至关重要。Polo样激酶1（PLK1）参与有丝分裂的多个阶段。叉头框蛋白M1（FOXM1）在肿瘤发生中具有多种功能，其水平升高常与癌症进展相关。本研究报道，作为PLK1底物的FOXM1控制着介导PLK1依赖性细胞周期调控的转录机制。本研究调查了PLK1和FOXM1在肾透明细胞癌769-P和ACHN细胞系中的表达，表明PLK1和FOXM1在人肾癌细胞系中的表达相关，且抑制PLK1可能降低FOXM1的表达。在肾癌细胞系中敲低FOXM1或PLK1会导致细胞周期进程受阻。因此，本研究表明FOXM1参与PLK1调控的细胞周期进程。