Lam Pikling, Kok Stanton Hon Lung, Lee Kenneth Ka Ho, Lam Kim Hung, Hau Desmond Kwok Po, Wong Wai Yeung, Bian Zhaoxiang, Gambari Roberto, Chui Chung Hin
State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, SAR, P.R. China.
School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, SAR, P.R. China.
Biomed Rep. 2016 Apr;4(4):449-452. doi: 10.3892/br.2016.608. Epub 2016 Feb 23.
() is an opportunistic fungal pathogen, particularly observed in immunocompromised patients. accounts for 50-70% of cases of invasive candidiasis in the majority of clinical settings. Terbinafine, an allylamine antifungal drug, has been used to treat fungal infections previously. It has fungistatic activity against . Traditional Chinese medicines can be used as complementary medicines to conventional drugs to treat a variety of ailments and diseases. Berberine is a quaternary alkaloid isolated from the traditional Chinese herb, , while berberrubine is isolated from the medicinal plant , but is also readily derived from berberine by pyrolysis. The present study demonstrates the possible complementary use of berberine and berberrubine with terbinafine against . The experimental findings assume that the potential application of these alkaloids together with reduced dosage of the standard drug would enhance the resulting antifungal potency.
（）是一种机会性真菌病原体，尤其在免疫功能低下的患者中观察到。在大多数临床环境中，（）占侵袭性念珠菌病病例的50 - 70%。特比萘芬是一种烯丙胺类抗真菌药物，此前已用于治疗真菌感染。它对（）具有抑菌活性。中药可作为传统药物的补充药物用于治疗各种疾病。黄连素是从传统中药（）中分离出的一种季铵生物碱，而小檗红碱是从药用植物（）中分离出来的，但也很容易通过热解从黄连素中衍生出来。本研究证明了黄连素和小檗红碱与特比萘芬联合使用对（）可能具有的补充作用。实验结果推测，这些生物碱与标准药物的减少剂量联合使用的潜在应用将增强最终的抗真菌效力。
