体内的多肽激素结合位点：通过电子显微镜放射自显影观察到，125I标记的胰岛素在肝细胞质膜上的初始定位。
Polypeptide hormone binding sites in vivo: initial localization of 125I-labeled insulin to hepatocyte plasmalemma as visualized by electron microscope radioautography.
作者信息
Bergeron J J, Levine G, Sikstrom R, O'Shaughnessy D, Kopriwa B, Nadler N J, Posner B I
出版信息
Proc Natl Acad Sci U S A. 1977 Nov;74(11):5051-5. doi: 10.1073/pnas.74.11.5051.
Abstract
The rationale of the specific-binding assay was applied to the detection of the liver insulin receptor in vivo. Quantitative electron microscope radioautography indicated that, 3 min after an intraportal injection, 125I-insulin was exclusively located to the hepatocyte plasmalemma.
摘要
特异性结合测定的原理被应用于体内肝脏胰岛素受体的检测。定量电子显微镜放射自显影表明，门静脉注射后3分钟，125I胰岛素仅定位在肝细胞膜上。
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