Belcher N G, Lee T H, Rees P J
Dept of Medicine and Respiratory Medicine, United Medical School, Guy's Hospital, London, England.
Eur Respir J. 1989 Jan;2(1):44-8.
The airway responses to histamine, exercise and ultrasonically nebulized hypertonic saline have been compared in ten asthmatic patients. The responses to hypertonic saline were not significantly different when the same volume of aerosol was given in a single dose or in 10 l aliquots, suggesting that the challenge is cumulative. The variability of the response to hypertonic saline challenge was not significantly different from that of exercise challenge. Response to hypertonic saline correlated significantly with exercise (r = 0.68, p less than 0.05) and with histamine response (r = 0.74, p less than 0.02), but the correlation between exercise and histamine was not statistically significant (r = 0.15, p greater than 0.1). These findings suggest that exercise-induced asthma has a closer relationship to bronchial responsiveness to hypertonic saline aerosol than it does to non-specific reactivity demonstrated by histamine challenge.
对10名哮喘患者的气道对组胺、运动及超声雾化高渗盐水的反应进行了比较。当给予相同体积的气雾剂时，单次剂量或10升等分剂量下对高渗盐水的反应无显著差异，提示激发是累积性的。高渗盐水激发反应的变异性与运动激发反应的变异性无显著差异。对高渗盐水的反应与运动显著相关（r = 0.68，p < 0.05），与组胺反应显著相关（r = 0.74，p < 0.02），但运动与组胺之间的相关性无统计学意义（r = 0.15，p > 0.1）。这些发现提示，运动诱发的哮喘与支气管对高渗盐雾气溶胶的反应性之间的关系，比与组胺激发所显示的非特异性反应性之间的关系更为密切。
