Ivashev M N, Martynova E R, Medvedev O S
Farmakol Toksikol. 1989 Jan-Feb;52(1):26-9.
The effect of cavinton (vinpocetine) on the systemic and regional hemodynamic parameters was studied by the radioactive microsphere technique in experiments on conscious and anesthetized rats. Intravenous administration of cavinton (10 mg/kg) was followed by the development of hypotension and bradycardia in conscious and anesthetized animals. Administration of cavinton to anesthetized rats increased the blood flow both in the brain and in most internal organs. In conscious animals the drug failed to increase the cerebral blood flow but increased the blood flow in the internal organs. It is suggested that dilation of the cerebral vessels under the influence of cavinton only in anesthetized rats could be related to a higher initial resistance of the cerebral vessels in anesthetized animals as compared with conscious ones.
采用放射性微球技术，在清醒和麻醉大鼠实验中研究了卡文通（长春西汀）对全身和局部血流动力学参数的影响。清醒和麻醉动物静脉注射卡文通（10mg/kg）后，均出现低血压和心动过缓。给麻醉大鼠注射卡文通可增加脑和大多数内脏器官的血流量。在清醒动物中，该药未能增加脑血流量，但增加了内脏器官的血流量。提示卡文通仅在麻醉大鼠中引起脑血管扩张，可能与麻醉动物脑血管初始阻力高于清醒动物有关。
