[新型脑血管制剂匹卡米隆]
[The new cerebrovascular preparation pikamilon].
作者信息
Mirzoian R S, Gan'shina T S
出版信息
Farmakol Toksikol. 1989 Jan-Feb;52(1):23-6.
PMID:2707413
Abstract
Picamilon, a sodium salt of N-nicotinoyl-gamma-aminobutyric acid, was shown to induce a significant increase of cerebral blood flow in conscious cats. Picamilon was found to inhibit neurogenic spasms of cerebral vessels that was followed by suppression of tonic activity and reflectory discharges in sympathetic nerves. Picamilon led to restoration of the initial condition of cerebral hemodynamics disturbed by a previous administration of serotonin.
摘要
匹卡米隆，即N - 烟酰基 - γ - 氨基丁酸的钠盐，已被证明能使清醒猫的脑血流量显著增加。发现匹卡米隆可抑制脑血管的神经源性痉挛，随后抑制交感神经的紧张性活动和反射性放电。匹卡米隆使先前给予血清素所扰乱的脑血流动力学恢复到初始状态。
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