Feuvray D, Leblond Y
Diabete Metab. 1984 Dec;10(5):316-23.
Long-chain free fatty acids which, in well-oxygenated hearts are the preferred metabolic fuel, are detrimental to cardiac function under ischemic conditions. A number of metabolic products accumulate in the cell during ischemia, among which are the long-chain acyl esters of CoA and carnitine. The presence of exogenous fatty acids during ischemic perfusion results in higher tissue levels of acyl carnitine. Diabetic hearts also have higher tissue levels of long-chain acyl-CoA and acyl carnitine. Moreover the increase of these long-chain acyl esters during ischemia is greater than in the normal hearts. The rise in long-chain acyl carnitine levels in the ischemic tissue correlates with the appearance of amorphous densities in the mitochondria and with structural alteration of the inner mitochondrial membrane. Accumulation of intermediates of fatty acid metabolism likely to contribute to cellular damage during ischemia.
在氧供应良好的心脏中，长链游离脂肪酸是首选的代谢燃料，但在缺血条件下对心脏功能有害。缺血期间细胞内会积累多种代谢产物，其中包括辅酶A和肉碱的长链酰基酯。缺血灌注期间外源性脂肪酸的存在会导致组织中酰基肉碱水平升高。糖尿病心脏组织中的长链酰基辅酶A和酰基肉碱水平也较高。此外，缺血期间这些长链酰基酯的增加幅度大于正常心脏。缺血组织中长链酰基肉碱水平的升高与线粒体中无定形密度的出现以及线粒体内膜的结构改变相关。脂肪酸代谢中间产物的积累可能导致缺血期间的细胞损伤。
