Imambaev S E
Farmakol Toksikol. 1989 Jan-Feb;52(1):59-61.
In the August rats kept for 30 days on adequate and low protein diet there was studied the effect of a single intragastric administration of phenyline, an anticoagulant of indirect action, in a dose of 15 mg/kg on parameters of the liver monooxygenase system (N-demethylase of amidopyrine, N-hydroxylase of aniline, content of cytochromes P-450 and B5). The parameters of the rat liver monooxygenase system of the animals kept on low protein diet decreased. Under adequate diet phenyline increased the activity of N-demethylase after 12 and 24 hours. Under low protein diet the preparation normalized some parameters of the liver monooxygenase system after 12 and 24 hours and the activity of N-demethylase and N-hydroxylase after 72 hours increased significantly.
对分别以充足蛋白质饮食和低蛋白饮食饲养30天的八月龄大鼠，研究了一次胃内给予剂量为15毫克/千克的间接作用抗凝剂苯乙苄胺对肝脏单加氧酶系统参数（氨基比林N-脱甲基酶、苯胺N-羟化酶、细胞色素P-450和B5的含量）的影响。以低蛋白饮食饲养的动物肝脏单加氧酶系统参数降低。在充足饮食条件下，苯乙苄胺在12小时和24小时后增加了N-脱甲基酶的活性。在低蛋白饮食条件下，该制剂在12小时和24小时后使肝脏单加氧酶系统的一些参数恢复正常，72小时后N-脱甲基酶和N-羟化酶的活性显著增加。
