Kharkevich D D, Kadagizde Z G
Farmakol Toksikol. 1989 Jan-Feb;52(1):61-4.
It was found that the stimulating effect of alpha-adrenomimetic mesatone in the test of lymphocyte adhesion inhibition in patients with rectum cancer in vitro was eliminated by beta-adrenergic blocker phentolamine and the inhibitory effect of beta-adrenergic antagonist propranolol. It was shown in vitro that lymphocyte chemoreceptor sensitivity to the stimulating effect of mesatone decreased and sensitivity to the inhibitory effect of isadrine increased in patients with advanced stages of rectum cancer.
研究发现，直肠癌患者体外淋巴细胞黏附抑制试验中，α-肾上腺素能激动剂间甲肾上腺素的刺激作用被β-肾上腺素能阻滞剂酚妥拉明及β-肾上腺素能拮抗剂普萘洛尔消除。体外研究表明，直肠癌晚期患者淋巴细胞化学感受器对间甲肾上腺素刺激作用的敏感性降低，而对异肾上腺素抑制作用的敏感性增加。
