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使用体内氙CT通气数据评估ΔV 4D CT通气计算方法并与其他方法进行比较。

Evaluation of the ΔV 4D CT ventilation calculation method using in vivo xenon CT ventilation data and comparison to other methods.

作者信息

Zhang Geoffrey G, Latifi Kujtim, Du Kaifang, Reinhardt Joseph M, Christensen Gary E, Ding Kai, Feygelman Vladimir, Moros Eduardo G

机构信息

Moffitt Cancer Center.

出版信息

J Appl Clin Med Phys. 2016 Mar 8;17(2):550-560. doi: 10.1120/jacmp.v17i2.5985.

DOI:10.1120/jacmp.v17i2.5985
PMID:27074479
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5874808/
Abstract

Ventilation distribution calculation using 4D CT has shown promising potential in several clinical applications. This study evaluated the direct geometric ventilation calculation method, namely the ΔV method, with xenon-enhanced CT (XeCT) ventilation data from four sheep, and compared it with two other published meth-ods, the Jacobian and the Hounsfield unit (HU) methods. Spearman correlation coefficient (SCC) and Dice similarity coefficient (DSC) were used for the evaluation and comparison. The average SCC with one standard deviation was 0.44 ± 0.13 with a range between 0.29 and 0.61 between the XeCT and ΔV ventilation distributions. The average DSC value for lower 30% ventilation volumes between the XeCT and ΔV ventilation distributions was 0.55 ± 0.07 with a range between 0.48 and 0.63. Ventilation difference introduced by deformable image registration errors improved with smoothing. In conclusion, ventilation distributions generated using ΔV-4D CT and deformable image registration are in reasonably agreement with the in vivo XeCT measured ventilation distribution.

摘要

使用4D CT进行通气分布计算在多个临床应用中已显示出有前景的潜力。本研究用来自四只绵羊的氙增强CT(XeCT)通气数据评估了直接几何通气计算方法,即ΔV方法,并将其与另外两种已发表的方法,即雅可比方法和亨氏单位(HU)方法进行比较。使用斯皮尔曼相关系数(SCC)和骰子相似系数(DSC)进行评估和比较。XeCT与ΔV通气分布之间的平均SCC及一个标准差为0.44±0.13,范围在0.29至0.61之间。XeCT与ΔV通气分布之间较低30%通气量的平均DSC值为0.55±0.07,范围在0.48至0.63之间。可变形图像配准误差引入的通气差异通过平滑得到改善。总之,使用ΔV - 4D CT和可变形图像配准生成的通气分布与体内XeCT测量的通气分布相当一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e9/5874808/46eb0344db7e/ACM2-17-550-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e9/5874808/43b4763bb3bc/ACM2-17-550-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e9/5874808/07e4d3166497/ACM2-17-550-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e9/5874808/5d1ab36db4dc/ACM2-17-550-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e9/5874808/46eb0344db7e/ACM2-17-550-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e9/5874808/43b4763bb3bc/ACM2-17-550-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e9/5874808/07e4d3166497/ACM2-17-550-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e9/5874808/5d1ab36db4dc/ACM2-17-550-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57e9/5874808/46eb0344db7e/ACM2-17-550-g004.jpg

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Analysis of Long-Term 4-Dimensional Computed Tomography Regional Ventilation After Radiation Therapy.放射治疗后长期四维计算机断层扫描区域通气分析
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Dosimetric impact of 4-dimensional computed tomography ventilation imaging-based functional treatment planning for stereotactic body radiation therapy with 3-dimensional conformal radiation therapy.
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N-Phase Local Expansion Ratio for Characterizing Out-of-Phase Lung Ventilation.用于描述不同时相肺通气的 N 相局部扩张比。
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