Popiołek Łukasz, Biernasiuk Anna
a Department of Organic Chemistry and.
b Department of Pharmaceutical Microbiology , Faculty of Pharmacy, Medical University of Lublin , Lublin , Poland.
J Enzyme Inhib Med Chem. 2016;31(sup1):62-69. doi: 10.3109/14756366.2016.1170012. Epub 2016 Apr 13.
A series of 28 hydrazide-hydrazones of 3-methoxybenzoic and 4-tert-butylbenzoic acid were synthesized and screened in vitro against the panel of reference strains of bacteria and fungi with the use of the broth microdilution method according to EUCAST and CLSI guidelines. Five of the synthesized compounds were found to exhibit high bacteriostatic or bactericidal activity against Gram-positive bacteria. The antimicrobial activity of compounds 13, 14, and 16 against Bacillus spp. was higher than that of commonly used antibiotics, like cefuroxime or ampicillin.
合成了一系列28种3-甲氧基苯甲酸和4-叔丁基苯甲酸的酰肼腙，并根据欧盟药敏试验委员会（EUCAST）和美国临床和实验室标准协会（CLSI）的指南，采用肉汤微量稀释法对一组细菌和真菌参考菌株进行了体外筛选。发现其中5种合成化合物对革兰氏阳性菌具有高抑菌或杀菌活性。化合物13、14和16对芽孢杆菌属的抗菌活性高于常用抗生素，如头孢呋辛或氨苄西林。
