Popiołek Łukasz, Biernasiuk Anna
Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, Poland.
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, Poland.
Saudi Pharm J. 2017 Nov;25(7):1097-1102. doi: 10.1016/j.jsps.2017.05.006. Epub 2017 May 26.
In this research we synthesized and tested for antimicrobial activity 21 nitrofurazone analogues. The compounds we obtained were identified on the basis of H NMR and C NMR spectroscopy. The screening of antimicrobial properties of synthesized compounds revealed a wide spectrum of antimicrobial activity. Compounds , , -, and - showed very high bactericidal effect towards spp. ATTC and spp. ATTC (MIC = 0.002-7.81 µg/ml and MBC = 0.002-31.25 µg/ml). The levels of activity of several compounds were far better than those of nitrofurantoin, ciprofloxacin or cefuroxime.
在本研究中，我们合成了21种呋喃西林类似物并测试了其抗菌活性。我们所得到的化合物是通过氢核磁共振光谱和碳核磁共振光谱鉴定的。对合成化合物抗菌性能的筛选显示出广泛的抗菌活性。化合物、、-和-对金黄色葡萄球菌ATCC和大肠杆菌ATCC表现出非常高的杀菌效果（最低抑菌浓度=0.002 - 7.81微克/毫升，最低杀菌浓度=0.002 - 31.25微克/毫升）。几种化合物的活性水平远优于呋喃妥因、环丙沙星或头孢呋辛。
