A 380-gene meta-signature of active tuberculosis compared with healthy controls.
作者信息
Blankley Simon, Graham Christine M, Levin Joe, Turner Jacob, Berry Matthew P R, Bloom Chloe I, Xu Zhaohui, Pascual Virgina, Banchereau Jacques, Chaussabel Damien, Breen Ronan, Santis George, Blankenship Derek M, Lipman Marc, O'Garra Anne
机构信息
Laboratory of Immunoregulation and Infection, The Francis Crick Institute, Mill Hill Laboratory (formerly The MRC National Institute for Medical Research), London, UK.
Baylor Research Institute, Baylor Scott & White, Dallas, TX, USA.
出版信息
Eur Respir J. 2016 Jun;47(6):1873-6. doi: 10.1183/13993003.02121-2015. Epub 2016 Apr 13.
Abstract
摘要
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本文引用的文献
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Type I interferons in infectious disease.传染病中的I型干扰素。
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The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis.转录组血液标志物在增强我们对宿主感染反应的理解中的应用：以结核病为例。
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Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study.采用全血 RNA 表达谱检测感染和未感染 HIV 的非洲成年人中的结核病：一项病例对照研究。
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A helicopter perspective on TB biomarkers: pathway and process based analysis of gene expression data provides new insight into TB pathogenesis.从直升机视角看结核病生物标志物：基于途径和过程的基因表达数据分析为结核病发病机制提供了新的见解。
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Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers.转录组血液标志物可区分肺结核、肺结节病、肺炎和肺癌。
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The immune response in tuberculosis.结核的免疫反应。
Annu Rev Immunol. 2013;31:475-527. doi: 10.1146/annurev-immunol-032712-095939.
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Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy.抗结核治疗两周后，血液转录组中出现可检测到的变化。
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J Infect Dis. 2013 Jan 1;207(1):18-29. doi: 10.1093/infdis/jis499. Epub 2012 Aug 7.
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