• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

环磷酰胺诱导的Wistar大鼠肝毒性：没食子酸作为一种具有肝保护和化学预防作用的植物化学物质的调节作用。

Cyclophosphamide-induced Hepatotoxicity in Wistar Rats: The Modulatory Role of Gallic Acid as a Hepatoprotective and Chemopreventive Phytochemical.

作者信息

Oyagbemi Ademola Adetokunbo, Omobowale Olutayo Temidayo, Asenuga Ebunoluwa Rachael, Akinleye Akinrinde Stephen, Ogunsanwo Rachael Omolola, Saba Adebowale Bernard

机构信息

Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.

Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.

出版信息

Int J Prev Med. 2016 Mar 1;7:51. doi: 10.4103/2008-7802.177898. eCollection 2016.

DOI:10.4103/2008-7802.177898
PMID:27076889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4809133/
Abstract

BACKGROUND

Gallic acid (GA) is an endogenous plant phenol known to have antioxidant, free radical scavenging ability, anti-inflammatory, anti-cancer, and anti-fungal properties. The aim of this study was to assess the protective effect of GA on cyclophosphamide (CPA)-induced hepatotoxicity in male Wistar rats.

METHODS

Sixty rats were grouped into six groups of 10 rats per group. Group 1 received distilled water. Group 2 received CPA at 200 mg/kg single dose intraperitoneally on day 1. Groups 3 and 4 received a single dose of CPA (200 mg/kg) intraperitoneally on day 1 and then were treated with GA at 60 and 120 mg/kg body weight for 14 days, respectively. Rats in Groups 5 and 6 only received GA at 60 and 120 mg/kg body weight for 14 days, respectively. GA was administered orally.

RESULTS

CPA induced hepatic damage as indicated by significant elevation (P < 0.05) in aspartate aminotransferase, organ weight, and evidence by the histological study. CPA also induced hepatic oxidative stress as indicated by significant elevation (P < 0.05) in malondialdehyde content, hydrogen peroxide (H2O2) generation, nitrite level, and the level of glutathione (GSH) peroxidase crashed in the CPA-treated group. GA enhanced the antioxidant defense system as indicated by significant elevation (P < 0.05) in GSH level, catalase activity, and GSH-S-transferase activity.

CONCLUSIONS

Taken together, the result of this present study shows that GA has a protective effect on CPA-induced hepatotoxicity.

摘要

背景

没食子酸（GA）是一种内源性植物酚，已知具有抗氧化、清除自由基能力、抗炎、抗癌和抗真菌特性。本研究的目的是评估GA对环磷酰胺（CPA）诱导的雄性Wistar大鼠肝毒性的保护作用。

方法

60只大鼠分为6组，每组10只。第1组给予蒸馏水。第2组在第1天腹腔注射200mg/kg单剂量的CPA。第3组和第4组在第1天腹腔注射单剂量的CPA（200mg/kg），然后分别用60mg/kg和120mg/kg体重的GA治疗14天。第5组和第6组的大鼠分别仅接受60mg/kg和120mg/kg体重的GA治疗14天。GA通过口服给药。

结果

CPA诱导肝损伤，表现为天冬氨酸转氨酶、器官重量显著升高（P<0.05），组织学研究也证实了这一点。CPA还诱导肝氧化应激，表现为丙二醛含量、过氧化氢（H2O2）生成、亚硝酸盐水平显著升高（P<0.05），且CPA治疗组谷胱甘肽（GSH）过氧化物酶水平下降。GA增强了抗氧化防御系统，表现为GSH水平、过氧化氢酶活性和GSH-S-转移酶活性显著升高（P<0.05）。

结论

综上所述，本研究结果表明GA对CPA诱导的肝毒性具有保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/83aae67bb887/IJPVM-7-51-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/6ee44d02ecd9/IJPVM-7-51-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/dc20e48e3bf4/IJPVM-7-51-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/42b80f4af94f/IJPVM-7-51-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/2b312dd2c2de/IJPVM-7-51-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/effe3812a4b1/IJPVM-7-51-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/8fa6fdee1711/IJPVM-7-51-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/52385fd62090/IJPVM-7-51-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/4a08d7c56218/IJPVM-7-51-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/5e7c17ad190f/IJPVM-7-51-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/dd4d2bafe2c9/IJPVM-7-51-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/83aae67bb887/IJPVM-7-51-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/6ee44d02ecd9/IJPVM-7-51-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/dc20e48e3bf4/IJPVM-7-51-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/42b80f4af94f/IJPVM-7-51-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/2b312dd2c2de/IJPVM-7-51-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/effe3812a4b1/IJPVM-7-51-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/8fa6fdee1711/IJPVM-7-51-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/52385fd62090/IJPVM-7-51-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/4a08d7c56218/IJPVM-7-51-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/5e7c17ad190f/IJPVM-7-51-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/dd4d2bafe2c9/IJPVM-7-51-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e15/4809133/83aae67bb887/IJPVM-7-51-g011.jpg

相似文献

1
Cyclophosphamide-induced Hepatotoxicity in Wistar Rats: The Modulatory Role of Gallic Acid as a Hepatoprotective and Chemopreventive Phytochemical.环磷酰胺诱导的Wistar大鼠肝毒性：没食子酸作为一种具有肝保护和化学预防作用的植物化学物质的调节作用。
Int J Prev Med. 2016 Mar 1;7:51. doi: 10.4103/2008-7802.177898. eCollection 2016.
2
Gallic Acid Ameliorates Cyclophosphamide-Induced Neurotoxicity in Wistar Rats Through Free Radical Scavenging Activity and Improvement in Antioxidant Defense System.没食子酸通过清除自由基活性和改善抗氧化防御系统减轻环磷酰胺诱导的Wistar大鼠神经毒性。
J Diet Suppl. 2016;13(4):402-19. doi: 10.3109/19390211.2015.1103827. Epub 2015 Dec 30.
3
Ameliorative Effect of Gallic Acid in Doxorubicin-Induced Hepatotoxicity in Wistar Rats Through Antioxidant Defense System.没食子酸通过抗氧化防御系统对阿霉素诱导的Wistar大鼠肝毒性的改善作用
J Diet Suppl. 2018 Mar 4;15(2):183-196. doi: 10.1080/19390211.2017.1335822. Epub 2017 Jul 18.
4
Gallic acid protects against cyclophosphamide-induced toxicity in testis and epididymis of rats.没食子酸可保护大鼠睾丸和附睾免受环磷酰胺诱导的毒性作用。
Andrologia. 2016 May;48(4):393-401. doi: 10.1111/and.12459. Epub 2015 Jul 29.
5
Gallic acid rescues uranyl acetate induced-hepatic dysfunction in rats by its antioxidant and cytoprotective potentials.没食子酸通过抗氧化和细胞保护作用，挽救醋酸铀酰所致大鼠肝损伤。
BMC Complement Med Ther. 2023 Nov 22;23(1):423. doi: 10.1186/s12906-023-04250-y.
6
18-β Glycyrrhetinic acid alleviates 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats: Role in hyperproliferation, inflammation and oxidative stress.18-β甘草次酸减轻2-乙酰氨基芴诱导的Wistar大鼠肝毒性：在细胞过度增殖、炎症和氧化应激中的作用
Hum Exp Toxicol. 2015 Jun;34(6):628-41. doi: 10.1177/0960327114554045. Epub 2014 Oct 28.
7
Ameliorative Effect of Gallic Acid on Methotrexate-Induced Hepatotoxicity and Nephrotoxicity in Rat.没食子酸对甲氨蝶呤诱导的大鼠肝毒性和肾毒性的改善作用
J Xenobiot. 2016 Aug 26;6(1):6092. doi: 10.4081/xeno.2016.6092. eCollection 2016 Jun 10.
8
Protective effects of Pycnogenol on carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats.碧萝芷对四氯化碳诱导的斯普拉格-道利大鼠肝毒性的保护作用。
Food Chem Toxicol. 2008 Jan;46(1):380-7. doi: 10.1016/j.fct.2007.08.016. Epub 2007 Aug 21.
9
Antioxidant and hepatoprotective activity of Fagonia schweinfurthii (Hadidi) Hadidi extract in carbon tetrachloride induced hepatotoxicity in HepG2 cell line and rats.没药属植物提取物对四氯化碳诱导的 HepG2 细胞和大鼠肝毒性的抗氧化和保肝作用。
J Ethnopharmacol. 2013 Dec 12;150(3):973-81. doi: 10.1016/j.jep.2013.09.048. Epub 2013 Oct 17.
10
Protective effects of gallic acid against methotrexate-induced toxicity in rats.没食子酸对甲氨蝶呤诱导的大鼠毒性的保护作用。
Acta Chir Belg. 2018 Jun;118(3):152-160. doi: 10.1080/00015458.2017.1394672. Epub 2017 Oct 25.

引用本文的文献

1
Molecular mechanisms underlying cyclophosphamide-induced ovarian injury and protective strategies.环磷酰胺诱导卵巢损伤的分子机制及保护策略
Naunyn Schmiedebergs Arch Pharmacol. 2025 Sep 12. doi: 10.1007/s00210-025-04550-9.
2
Modulation of Glutathione-S-Transferase by Phytochemicals: To Activate or Inhibit-That Is the Question.植物化学物质对谷胱甘肽-S-转移酶的调节作用：激活还是抑制——这是个问题。
Int J Mol Sci. 2025 Jul 25;26(15):7202. doi: 10.3390/ijms26157202.
3
Gallic acid mitigates high-fat and high-carbohydrate diet-induced steatohepatitis by modulating the IRF6/PPARγ signaling pathway.

本文引用的文献

1
Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPARγ and abrogation of oxidative stress and inflammation.橙皮苷通过上调过氧化物酶体增殖物激活受体γ（PPARγ）以及消除氧化应激和炎症来预防环磷酰胺诱导的肝毒性。
Can J Physiol Pharmacol. 2014 Sep;92(9):717-24. doi: 10.1139/cjpp-2014-0204. Epub 2014 Jun 16.
2
Flavonols and derivatives of gallic acid from young leaves of Toona sinensis (A. Juss.) Roemer and evaluation of their anti-oxidant capacity by chemical methods.香椿（Toona sinensis (A. Juss.) Roemer）幼叶中的黄酮醇和没食子酸衍生物及其抗氧化能力的化学方法评价
Pharmacogn Mag. 2014 Apr;10(38):185-90. doi: 10.4103/0973-1296.131034.
3
没食子酸通过调节IRF6/PPARγ信号通路减轻高脂高碳水化合物饮食诱导的脂肪性肝炎。
Front Pharmacol. 2025 Apr 1;16:1563561. doi: 10.3389/fphar.2025.1563561. eCollection 2025.
4
seed oil shields against cyclophosphamide-induced hepatorenal toxicity by modulating redox imbalance and iNOS/IL-β1 signalling in rats.籽油通过调节大鼠体内的氧化还原失衡和诱导型一氧化氮合酶/白细胞介素-β1信号通路，对环磷酰胺诱导的肝肾毒性起到保护作用。
Heliyon. 2025 Jan 6;11(2):e41624. doi: 10.1016/j.heliyon.2025.e41624. eCollection 2025 Jan 30.
5
Therapeutic Potential of Capsaicin against Cyclophosphamide-Induced Liver Damage.辣椒素对环磷酰胺诱导的肝损伤的治疗潜力
J Clin Med. 2023 Jan 24;12(3):911. doi: 10.3390/jcm12030911.
6
Potential protective effect of escin from extract against cyclophosphamide-induced oxidative stress on rat tissues.七叶皂苷提取物对环磷酰胺诱导的大鼠组织氧化应激的潜在保护作用。
Toxicol Res (Camb). 2022 Sep 1;11(5):812-818. doi: 10.1093/toxres/tfac059. eCollection 2022 Oct.
7
Antioxidative and Energy Metabolism-Improving Effects of Maca Polysaccharide on Cyclophosphamide-Induced Hepatotoxicity Mice via Metabolomic Analysis and Keap1-Nrf2 Pathway.通过代谢组学分析和 Keap1-Nrf2 通路研究玛咖多糖对环磷酰胺致肝损伤小鼠的抗氧化和能量代谢改善作用。
Nutrients. 2022 Oct 12;14(20):4264. doi: 10.3390/nu14204264.
8
Lactobionic Acid Conjugated Quercetin Loaded Organically Modified Silica Nanoparticles Mitigates Cyclophosphamide Induced Hepatocytotoxicity.乳醛酸结合槲皮素负载有机改性硅纳米粒子减轻环磷酰胺诱导的肝细胞毒性。
Int J Nanomedicine. 2019 Nov 18;14:8943-8959. doi: 10.2147/IJN.S218577. eCollection 2019.
9
Bioactivity and modulatory functions of on oxidative stress-induced micronuclei and apoptotic biomarkers in mice.[物质名称]对小鼠氧化应激诱导的微核及凋亡生物标志物的生物活性和调节功能。 （原文中“of”后面缺少具体物质，这里补充了[物质名称]以使译文完整）
Toxicol Rep. 2019 Sep 22;6:963-974. doi: 10.1016/j.toxrep.2019.09.007. eCollection 2019.
10
Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis.白杨素通过抑制氧化应激、炎症和细胞凋亡对环磷酰胺诱导的肝毒性和肾毒性的保护作用。
Naunyn Schmiedebergs Arch Pharmacol. 2020 Mar;393(3):325-337. doi: 10.1007/s00210-019-01741-z. Epub 2019 Oct 16.
Gallic acid inhibits migration and invasion of SCC-4 human oral cancer cells through actions of NF-κB, Ras and matrix metalloproteinase-2 and -9.
没食子酸通过核因子κB、Ras以及基质金属蛋白酶-2和-9的作用抑制SCC-4人舌癌细胞的迁移和侵袭。
Oncol Rep. 2014 Jul;32(1):355-61. doi: 10.3892/or.2014.3209. Epub 2014 May 23.
4
Gallic acid reduces cell viability, proliferation, invasion and angiogenesis in human cervical cancer cells.没食子酸降低人宫颈癌细胞的细胞活力、增殖、侵袭和血管生成。
Oncol Lett. 2013 Dec;6(6):1749-1755. doi: 10.3892/ol.2013.1632. Epub 2013 Oct 15.
5
Failure of recovery from lead induced hepatoxicity and disruption of erythrocyte antioxidant defence system in Wistar rats.Wistar大鼠铅诱导的肝毒性恢复失败及红细胞抗氧化防御系统破坏
Environ Toxicol Pharmacol. 2014 May;37(3):1202-11. doi: 10.1016/j.etap.2014.03.002. Epub 2014 Mar 28.
6
Antioxidant activity of gallic acid and methyl gallate in triacylglycerols of Kilka fish oil and its oil-in-water emulsion.没食子酸和没食子酸甲酯在 kilka 鱼油及其水包油乳液三酰甘油中的抗氧化活性。
Food Chem. 2014 Sep 15;159:439-44. doi: 10.1016/j.foodchem.2014.03.038. Epub 2014 Mar 18.
7
Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines.小檗碱通过调节抗氧化状态和炎性细胞因子减轻环磷酰胺诱导的肝毒性。
J Cancer Res Clin Oncol. 2014 Jul;140(7):1103-9. doi: 10.1007/s00432-014-1665-8. Epub 2014 Apr 18.
8
Protective effects of gallic acid against chronic cerebral hypoperfusion-induced cognitive deficit and brain oxidative damage in rats.没食子酸对大鼠慢性脑灌注不足诱导的认知缺陷和脑氧化损伤的保护作用。
Eur J Pharmacol. 2014 Jun 15;733:62-7. doi: 10.1016/j.ejphar.2014.03.044. Epub 2014 Apr 12.
9
Gallic acid functions as a TRPA1 antagonist with relevant antinociceptive and antiedematogenic effects in mice.没食子酸在小鼠中作为一种TRPA1拮抗剂发挥作用，具有相关的镇痛和抗水肿作用。
Naunyn Schmiedebergs Arch Pharmacol. 2014 Jul;387(7):679-89. doi: 10.1007/s00210-014-0978-0. Epub 2014 Apr 11.
10
Lack of reversal of oxidative damage in renal tissues of lead acetate-treated rats.醋酸铅处理的大鼠肾组织中氧化损伤未得到逆转。
Environ Toxicol. 2015 Nov;30(11):1235-43. doi: 10.1002/tox.21994. Epub 2014 Apr 5.