Schwalb H, Dirschedl P
Institut f. Med. Informationsverarbeitung, Statistik u. Biomathematik, München.
Fortschr Neurol Psychiatr. 1989 Mar;57(3):119-23. doi: 10.1055/s-2007-1000752.
In a long-term study involving 783 psychic patients (361 men and 422 women) ranging in age between 40 and 70 years and hospitalised for extended periods of time, who had been examined for the incidence of cardiovascular diseases and risk factors, the cardiovascular mortality was registered for a period of 10 years. Using a multiple logistic model, an attempt was made at assessing the mortality risk in dependence on 14 parameters. The most conclusive predictor proved to be the pathological ECG which was seen to reflect seven times a higher risk. In addition to age and sex - the cardiovascular mortality of men was twice and a half that of women - hypertension and increased serum cholesterol levels among the known risk factors revealed a significant influence with little less than a doubling of the risk. On the other hand, a correlation to cardiovascular mortality was neither established for the kind of psychic disease nor for the kind of psychopharmacotherapy.
在一项长期研究中,涉及783名年龄在40至70岁之间、长期住院的精神疾病患者(361名男性和422名女性),这些患者接受了心血管疾病发病率和风险因素的检查,并记录了他们10年的心血管死亡率。使用多元逻辑模型,尝试根据14个参数评估死亡风险。最具决定性的预测因素被证明是病理性心电图,其反映出的风险高出七倍。除了年龄和性别——男性的心血管死亡率是女性的两倍半——高血压和已知风险因素中血清胆固醇水平升高显示出显著影响,风险几乎翻倍。另一方面,无论是精神疾病类型还是精神药物治疗类型,均未发现与心血管死亡率存在相关性。