de Martino M, Rossi M E, Novembre E, Vierucci A
Department of Pediatrics, University of Florence, Italy.
Ann Allergy. 1988 Oct;61(4):253-8.
Occurrence and subclass distribution of IgG to alpha-lactalbumin (ALA), beta-lactoglobulin (BLG), and ovalbumin (OA) have been determined in 30 children with atopic dermatitis (AD) and in their mothers. Thirty nonatopic (NA) children and their mothers were studied as controls. Total IgE and IgE to ALA, BLG, OA, Dermatophagoides pteronyssinus, and Lolium perenne were also investigated. The main purpose of this study was to determine whether in humans, as observed in animals, maternal allergen-specific IgG influences allergen-specific IgE synthesis in children. IgG1, IgG2, IgG3, and IgG4 to ALA, and IgG1 and IgG2 to OA were more frequent in AD children than in NA children. As compared with mothers of NA children, mothers of AD children had similar frequency and levels of IgG subclasses to BLG and to OA, but a higher frequency of IgG1, IgG2, and IgG3 to ALA. In no case did total or allergen-specific IgE levels correlate with any subclass of allergen-specific IgG, which in turn influenced neither total IgE levels nor allergen-specific IgE distribution. The presence of allergen-specific IgG of any subclass in mothers was not associated with modifications in total IgE levels nor in allergen-specific IgG subclass distribution in AD children. But occurrence of IgE to OA was higher in AD children whose mothers had IgG4 to OA. This finding may be a model of interference in specific IgE response in the child caused by isotype response in the mother.
已测定30例特应性皮炎（AD）患儿及其母亲体内针对α-乳白蛋白（ALA）、β-乳球蛋白（BLG）和卵清蛋白（OA）的IgG的发生率及亚类分布。研究了30例非特应性（NA）儿童及其母亲作为对照。还调查了总IgE以及针对ALA、BLG、OA、粉尘螨和黑麦草的IgE。本研究的主要目的是确定在人类中，是否如在动物中观察到的那样，母体过敏原特异性IgG会影响儿童过敏原特异性IgE的合成。AD患儿中针对ALA的IgG1、IgG2、IgG3和IgG4以及针对OA的IgG1和IgG2比NA患儿更常见。与NA患儿的母亲相比，AD患儿的母亲针对BLG和OA的IgG亚类的频率和水平相似，但针对ALA的IgG1、IgG2和IgG3的频率更高。在任何情况下，总IgE或过敏原特异性IgE水平均与过敏原特异性IgG的任何亚类均无相关性，而过敏原特异性IgG亚类又既不影响总IgE水平，也不影响过敏原特异性IgE的分布。母亲体内任何亚类的过敏原特异性IgG的存在与AD患儿的总IgE水平变化或过敏原特异性IgG亚类分布均无关。但是，母亲体内有针对OA的IgG4的AD患儿中，针对OA的IgE发生率更高。这一发现可能是母亲的同种型反应对儿童特异性IgE反应产生干扰的一个模型。
