Liu Ying, Yin Yanfei, Zhang Defa, Wang Menghong, Bi Yongqiang
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2015 Dec;32(6):1207-11.
Pulse waves contain abundant physiological and pathological information of human body. Research of the relationship between pulse wave and human cardiovascular physiological parameters can not only help clinical diagnosis and treatment of cardiovascular diseases, but also contribute to develop many new medical instruments. Based on the traditional double elastic cavity model, the human cardiovascular system was established by using the electric network model in this paper. The change of wall pressure and blood flow in artery was simulated. And the influence of the peripheral resistance and vessel compliance to the distribution of blood flow in artery was analyzed. The simulation results were compared with the clinical monitoring results to predict the physiological and pathological state of human body. The result showed that the simulation waveform of arterial wall pressure and blood flow was stabile after the second cardiac cycle. With the increasing of peripheral resistance, the systolic blood pressure of artery increased, the diastolic blood pressure had no significant change, and the pulse pressure of artery increased gradually. With the decreasing of vessel compliance, the vasoactivity became worse and the pulse pressure increased correspondingly. The simulation results were consistent with the clinical monitoring results. The increasing of peripheral resistance and decreasing of vascular compliance indicated that the incidence of hypertension and atherosclerosis was increased.
脉搏波包含人体丰富的生理和病理信息。研究脉搏波与人体心血管生理参数之间的关系，不仅有助于心血管疾病的临床诊断和治疗，还能为开发许多新型医疗器械做出贡献。本文基于传统的双弹性腔模型，利用电路网络模型建立了人体心血管系统。模拟了动脉壁压力和血流的变化。分析了外周阻力和血管顺应性对动脉血流分布的影响。将模拟结果与临床监测结果进行比较，以预测人体的生理和病理状态。结果表明，在第二个心动周期后，动脉壁压力和血流的模拟波形稳定。随着外周阻力的增加，动脉收缩压升高，舒张压无明显变化，动脉脉压逐渐增大。随着血管顺应性的降低，血管活性变差，脉压相应增加。模拟结果与临床监测结果一致。外周阻力增加和血管顺应性降低表明高血压和动脉粥样硬化的发病率增加。
