Scheuren Raymonde, Duschek Stefan, Schulz André, Sütterlin Stefan, Anton Fernand
Institute for Health and Behavior, Integrative Research Unit on Social and Individual Development (INSIDE), University of Luxembourg, Luxembourg, Luxembourg.
Institute of Psychology, UMIT-University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria.
Psychophysiology. 2016 Aug;53(8):1282-91. doi: 10.1111/psyp.12658. Epub 2016 Apr 15.
Numerous studies have documented an inverse relationship between blood pressure and sensitivity to experimental nociceptive stimulation. The present study aimed to investigate possible associations between blood pressure and the occurrence and intensity of paradoxical pain induced by the thermal grill paradigm. Thirty-one healthy subjects were stimulated three times for 1 min with the nonnoxious temperatures of 15°C and 41°C set at the interlaced cold and warm bars of a water bath-driven thermal grill. Blood pressure and heart rate were recorded concomitantly. On account of previous observations of an association between the sensitivity of the cardiac baroreflex and pain perception, this parameter was additionally obtained. Numerical rating scales were used to quantify subjective pain intensity and pain unpleasantness; subjects were classified as responders and nonresponders to thermal grill stimulation based on pain intensity ratings. Responders exhibited lower systolic and diastolic blood pressure than nonresponders, and inverse linear associations arose between blood pressure and pain intensity and unpleasantness. Baroreflex sensitivity was unrelated to pain ratings. The findings confirmed the hypothesis of a blood pressure dependence of paradoxical pain and support the notion that the cardiovascular and pain regulatory systems interact not only in the processing of pain elicited by noxious input, but also in nonnoxiously generated illusive pain. While this finding is not consistent with the assumption of an involvement of the baroreflex system in mediating the observed interaction, psychological traits and neurochemical factors are alternatively considered.
众多研究记录了血压与对实验性伤害性刺激的敏感性之间的负相关关系。本研究旨在调查血压与热烤架范式诱发的矛盾性疼痛的发生及强度之间可能存在的关联。31名健康受试者在水浴驱动的热烤架交错排列的冷、温条上，用15°C和41°C的非伤害性温度进行了3次每次1分钟的刺激。同时记录血压和心率。鉴于之前观察到心脏压力反射敏感性与疼痛感知之间存在关联，还额外获取了该参数。使用数字评分量表来量化主观疼痛强度和疼痛不适感；根据疼痛强度评分将受试者分为热烤架刺激的反应者和无反应者。反应者的收缩压和舒张压低于无反应者，并且血压与疼痛强度和不适感之间出现了负向线性关联。压力反射敏感性与疼痛评分无关。这些发现证实了矛盾性疼痛依赖血压的假设，并支持了心血管和疼痛调节系统不仅在处理有害输入引发的疼痛时相互作用，而且在非有害产生的幻觉性疼痛中也相互作用的观点。虽然这一发现与压力反射系统参与介导所观察到的相互作用的假设不一致，但心理特征和神经化学因素被作为替代考虑因素。
