脂联素在肥胖相关女性特发性致癌中的作用。

The role of adiponectin in obesity-associated female-specific carcinogenesis.

机构信息

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States; Department of Biotechnology, Berhampur University, Bhanjavihar, Berhampur, Odisha 760 007, India.

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, United States; Department of Microbiology, Banasthali University, Banasthali, Rajasthan 304022, India.

出版信息

Cytokine Growth Factor Rev. 2016 Oct;31:37-48. doi: 10.1016/j.cytogfr.2016.03.014. Epub 2016 Apr 6.

DOI:10.1016/j.cytogfr.2016.03.014

PMID:27079372

Abstract

Adipose tissue is a highly vascularized endocrine organ, and its secretion profiles may vary with obesity. Adiponectin is secreted by adipocytes that make up adipose tissue. Worldwide, obesity has been designated a serious health problem among women and is associated with a variety of metabolic disorders and an increased risk of developing cancer of the cervix, ovaries, uterus (uterine/endometrial), and breast. In this review, the potential link between obesity and female-specific malignancies is comprehensively presented by discussing significant features of the intriguing and complex molecule, adiponectin, with a focus on recent findings highlighting its molecular mechanism of action in female-specific carcinogenesis.

摘要

脂肪组织是一个高度血管化的内分泌器官，其分泌谱可能随肥胖而变化。脂联素由构成脂肪组织的脂肪细胞分泌。在全球范围内，肥胖已被定为女性的严重健康问题，与多种代谢紊乱以及宫颈癌、卵巢癌、子宫（子宫/子宫内膜）癌和乳腺癌的发病风险增加有关。在这篇综述中，通过讨论这个有趣而复杂的分子——脂联素的重要特征，全面阐述了肥胖与女性特有的恶性肿瘤之间的潜在联系，重点介绍了最近发现的其在女性特发性致癌作用中的分子机制。