Ma Xin, Yang Shaofeng, Li Donghai
Department of Thyroid Breast Surgery, Inner Mongolia Medical University, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Cancer Control. 2025 Jan-Dec;32:10732748251347917. doi: 10.1177/10732748251347917. Epub 2025 Jun 10.
Breast cancer remains the malignant tumor with the highest incidence among female patients globally, and its treatment represents a well-recognized clinical challenge. Recent studies have demonstrated that the tumor microenvironment (TME) exerts a substantial influence on breast cancer progression, whereby alterations in its internal molecular components ultimately impact disease outcomes. Key factors implicated in this process include adipokines and microRNAs (miRNAs). This review provides a detailed description of how different adipocytokines exert specific mechanistic effects on breast cancer cells. By integrating adipokines with miRNAs, the discussion explores their combined roles in the initiation and progression of breast cancer, addressing a previously unaddressed research gap in studies focusing solely on individual adipokines. Furthermore, by examining the interactions between miRNAs and signaling pathways, this analysis offers a holistic perspective on the TME network, thereby fostering new therapeutic insights for breast cancer management.
乳腺癌仍然是全球女性患者中发病率最高的恶性肿瘤，其治疗是一个公认的临床挑战。最近的研究表明，肿瘤微环境（TME）对乳腺癌进展有重大影响，其内部分子成分的改变最终会影响疾病的结局。参与这一过程的关键因素包括脂肪因子和微小RNA（miRNA）。本综述详细描述了不同脂肪细胞因子如何对乳腺癌细胞发挥特定的机制作用。通过将脂肪因子与miRNA整合，探讨了它们在乳腺癌发生和进展中的联合作用，填补了以往仅关注单个脂肪因子的研究中未涉及的研究空白。此外，通过研究miRNA与信号通路之间的相互作用，本分析提供了对TME网络的整体视角，从而为乳腺癌管理带来新的治疗思路。
