Shen Juan, Kai Jun, Tang Yuping, Zhang Li, Su Shulan, Duan Jin-Ao
1 Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese, Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Am J Chin Med. 2016;44(2):253-73. doi: 10.1142/S0192415X16500154.
Kansui, the root of Euphorbia kansui T.N. Liou ex T.P. Wang, is a well-known traditional Chinese medicine. This paper reviews advances in investigations of the botany, the phytochemistry, the analytical method, the pharmacology and the toxicology of kansui. Nearly 100 compounds have been isolated from kansui and identified, and diterpenes and triterpenes are considered to be the characteristic and bio-active constituents of kansui. They possess multiple pharmacological activities, including diuretic, purgation, and antitumor effects. However, they also have a degree of toxicity, and can cause skin, oral, and gastrointestinal irritation. In this paper, the toxicity-efficacy relationship, attenuation and incompatibility of kansui are further discussed. Several future investigations of kansui are also proposed, all of which would improve the identification of kansui and other toxic herbs, as well as further their utilization.
甘遂是大戟科大戟属植物甘遂的根，是一种著名的中药材。本文综述了甘遂在植物学、植物化学、分析方法、药理学和毒理学研究方面的进展。从甘遂中已分离鉴定出近100种化合物，二萜类和三萜类被认为是甘遂的特征性和生物活性成分。它们具有多种药理活性，包括利尿、泻下和抗肿瘤作用。然而，它们也有一定程度的毒性，可引起皮肤、口腔和胃肠道刺激。本文进一步讨论了甘遂的毒效关系、炮制及配伍禁忌。还提出了未来对甘遂的几项研究，所有这些都将有助于提高对甘遂及其他有毒草药的鉴定，并进一步促进它们的利用。
