Balottin U, Bejor M, Cecchini A, Martelli A, Palazzi S, Lanzi G
Division of Child Neuro-Psychiatry, Istituto C, Mondino, University of Pavia, Italy.
J Autism Dev Disord. 1989 Mar;19(1):109-17. doi: 10.1007/BF02212722.
The hypothesis that specific computerized tomography brain-scan findings are associated with infantile autism was tested in 45 cases and 19 controls. The autistic group was subdivided into serious and less-serious language-impaired subgroups. The analysis of Euclidean Distances, a type of cluster analysis, showed that neuroradiological parameters of cases and controls, including ventricular sizes, were on the whole significantly different, but no statistically significant difference appeared between the two autistic subgroups. But the analysis of variance of each neuroradiological parameter did not show any significant difference between autistics and controls. It was concluded that autism is nonspecifically associated with brain-scan abnormalities, and that other nonorganic, as well as organic, factors should be taken into account.
针对特定计算机断层扫描脑部扫描结果与婴儿自闭症相关这一假设，在45例病例和19名对照中进行了测试。自闭症组被细分为严重语言障碍亚组和轻度语言障碍亚组。聚类分析中的欧几里得距离分析表明，病例组和对照组的神经放射学参数，包括脑室大小，总体上有显著差异，但两个自闭症亚组之间没有统计学上的显著差异。然而，对每个神经放射学参数的方差分析并未显示自闭症患者与对照组之间有任何显著差异。研究得出结论，自闭症与脑部扫描异常无特异性关联，其他非器质性以及器质性因素均应予以考虑。
