Hoshino Y, Manome T, Kaneko M, Yashima Y, Kumashiro H
Folia Psychiatr Neurol Jpn. 1984;38(1):33-43. doi: 10.1111/j.1440-1819.1984.tb00352.x.
In order to examine the cranial CT of autistic children and investigate the etiological significance of CT scan findings, the CT of the brain was surveyed in 24 children with early infantile autism (3 to 17 years with a mean age of 7.6), and 179 children with the normal CT despite their medical histories such as headaches or febrile convulsions. According to their ages, the autistic and normal children were divided into the following three groups: Group I (age ranging from 3 to 5), Group II (age: 6 to 9) and Group III (age: 10 to 17). There was no significant difference between the bifrontal CVI of the autistic children and that of the normal children. However, in Group III, the bifrontal CVI of the autistic children was significantly higher than that of the normal children. There was no significant difference between the bicaudate CVI of the autistic children and that of the normal children. However, in Groups I and II, the bicaudate CVI of the autistic children was significantly lower than that of the normal children. The maximum widths of the third ventricle showed no significant difference between the autistic and normal children. However, in Groups II and III, those of the autistic children were wider than those of the normal children. In the autistic children, as the age increases, the difference becomes significantly wider. A positive correlation was observed between the width of the third ventricle and ages of the autistic children. An examination of the right-left ratio of maximum transverse diameter of the brain showed that there was no significant difference between the autistic and normal children. The above-mentioned results (1)-4)) might suggest a progressive disorder of the brain structure surrounding the third ventricle or lateral ventricles in the autistic children.
为了检查自闭症儿童的头颅CT并探讨CT扫描结果的病因学意义，对24例早期婴儿自闭症患儿（年龄3至17岁，平均年龄7.6岁）以及179例虽有头痛或高热惊厥等病史但CT正常的儿童进行了脑部CT检查。根据年龄，将自闭症儿童和正常儿童分为以下三组：第一组（年龄3至5岁）、第二组（年龄6至9岁）和第三组（年龄10至17岁）。自闭症儿童的双侧额叶脑白质容积（CVI）与正常儿童之间无显著差异。然而，在第三组中，自闭症儿童的双侧额叶CVI显著高于正常儿童。自闭症儿童的双侧尾状核CVI与正常儿童之间无显著差异。然而，在第一组和第二组中，自闭症儿童的双侧尾状核CVI显著低于正常儿童。第三脑室的最大宽度在自闭症儿童和正常儿童之间无显著差异。然而，在第二组和第三组中，自闭症儿童的第三脑室最大宽度比正常儿童更宽。在自闭症儿童中，随着年龄增长，差异变得更加显著。第三脑室宽度与自闭症儿童年龄之间存在正相关。对脑最大横径的左右比例检查显示，自闭症儿童和正常儿童之间无显著差异。上述结果（1）-4））可能提示自闭症儿童第三脑室或侧脑室周围脑结构存在进行性病变。
