CD8(+) T细胞主要通过识别寄生虫II型和III型菌株共同表达或交叉反应的表位，清除大脑中的弓形虫囊肿。
CD8(+) T cells remove cysts of Toxoplasma gondii from the brain mostly by recognizing epitopes commonly expressed by or cross-reactive between type II and type III strains of the parasite.
作者信息
Ochiai Eri, Sa Qila, Perkins Sara, Grigg Michael E, Suzuki Yasuhiro
机构信息
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Microbes Infect. 2016 Jul-Aug;18(7-8):517-22. doi: 10.1016/j.micinf.2016.03.013. Epub 2016 Apr 12.
Our previous study demonstrated that CD8(+) T cells remove cysts of Toxoplasma gondii from the brain through perforin-mediated mechanisms. We here show that a transfer of CD8(+) immune T cells primed with a type II or a type III strain of T. gondii both efficiently removed cysts of a type II strain from infected SCID mice, although the former tended to be slightly more efficient than the latter. Similarly, a transfer of type II-primed CD8(+) T cells removed cysts of a type III strain. Therefore, CD8(+) T cells are capable of removing T. gondii cysts by recognizing epitopes commonly expressed in types II and III strains or cross-reactive between these two genotypes.
我们之前的研究表明，CD8(+) T细胞通过穿孔素介导的机制清除脑内的弓形虫囊肿。我们在此表明，用弓形虫II型或III型菌株致敏的CD8(+)免疫T细胞的转移，均能有效清除感染的SCID小鼠体内II型菌株的囊肿，尽管前者的效率往往略高于后者。同样，用II型致敏的CD8(+) T细胞的转移也能清除III型菌株的囊肿。因此，CD8(+) T细胞能够通过识别II型和III型菌株中共同表达的表位或这两种基因型之间的交叉反应表位来清除弓形虫囊肿。
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