Rojas-Morales Pedro, Tapia Edilia, Pedraza-Chaverri José
Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Laboratorio de Fisiopatología Renal, Departamento de Nefrología, Instituto Nacional de Cardiología - Ignacio Chávez, Mexico City, Mexico.
Cell Signal. 2016 Aug;28(8):917-23. doi: 10.1016/j.cellsig.2016.04.005. Epub 2016 Apr 13.
Ketone bodies β-hydroxybutyrate (BHB) and acetoacetate are important metabolic substrates for energy production during prolonged fasting. However, BHB also has signaling functions. Through several metabolic pathways or processes, BHB modulates nutrient utilization and energy expenditure. These findings suggest that BHB is not solely a metabolic intermediate, but also acts as a signal to regulate metabolism and maintain energy homeostasis during nutrient deprivation. We briefly summarize the metabolism and emerging physiological functions of ketone bodies and highlight the potential role for BHB as a signaling molecule in starvation response.
酮体β-羟基丁酸酯（BHB）和乙酰乙酸是长期禁食期间能量产生的重要代谢底物。然而，BHB也具有信号传导功能。通过多种代谢途径或过程，BHB调节营养物质的利用和能量消耗。这些发现表明，BHB不仅是一种代谢中间产物，还作为一种信号，在营养缺乏期间调节代谢并维持能量稳态。我们简要总结了酮体的代谢和新出现的生理功能，并强调了BHB作为饥饿反应中信号分子的潜在作用。
