Baker Chaya Rochel, Domínguez D Juan F, Stout Julie C, Gabery Sanaz, Churchyard Andrew, Chua Phyllis, Egan Gary F, Petersén Åsa, Georgiou-Karistianis Nellie, Poudel Govinda R
School of Psychological Sciences/Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Victoria, Australia.
Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.
J Neurol Sci. 2016 May 15;364:148-53. doi: 10.1016/j.jns.2016.03.021. Epub 2016 Mar 12.
Subjective reports of sleep disturbance are a common feature of Huntington's disease (HD); however, there is limited research investigating the relationship between sleep problems with changes in brain and behaviour. This study aimed to investigate whether subjective reports of sleep problems in HD are associated with brain volume, neurocognitive decline, and neuropsychiatric symptoms. This retrospective pilot study used brain volume, neurocognitive and neuropsychiatric data from premanifest (pre-HD) and symptomatic HD (symp-HD). Subjective sleep problem was measured using the sleep item of the Beck's Depression Inventory-II (BDI-II). Pre-HD individuals reporting sleep problems had significantly poorer neuropsychiatric outcomes compared to those not reporting sleep problems. In the symp-HD group, those with sleep problems had significantly accelerated thalamic degeneration and poorer neuropsychiatric outcomes compared to those without sleep problems. There was no relationship between subjective sleep problems and neurocognitive measures. These findings suggest an association between subjective sleep disturbance, neuropathology, and development of neuropsychiatric symptoms in HD. Further studies using quantitative EEG-based monitoring of sleep in HD and changes in the brain and behaviour will be necessary to establish the causal nature of this relationship.
睡眠障碍的主观报告是亨廷顿舞蹈症（HD）的一个常见特征；然而，研究睡眠问题与大脑及行为变化之间关系的研究有限。本研究旨在调查HD中睡眠问题的主观报告是否与脑容量、神经认知衰退及神经精神症状相关。这项回顾性试点研究使用了临床前（HD前期）和有症状HD（症状性HD）的脑容量、神经认知和神经精神数据。使用贝克抑郁量表第二版（BDI-II）的睡眠项目来测量主观睡眠问题。与未报告睡眠问题的个体相比，报告睡眠问题的HD前期个体的神经精神预后明显更差。在症状性HD组中，与没有睡眠问题的个体相比，有睡眠问题的个体丘脑退化明显加速，神经精神预后更差。主观睡眠问题与神经认知指标之间没有关系。这些发现表明HD中主观睡眠障碍、神经病理学与神经精神症状发展之间存在关联。有必要开展进一步研究，通过基于定量脑电图的HD睡眠监测以及大脑和行为变化来确定这种关系的因果性质。
