Turner Mitchell, Bartlett Danielle, Poudel Govinda, Zaenker Pauline, Laws Simon, Lo Johnny, Ziman Mel, Cruickshank Travis
Centre for Precision Health, Edith Cowan University, Perth, WA, Australia.
School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Sleep Sci. 2024 Feb 15;17(2):e199-e202. doi: 10.1055/s-0043-1777783. eCollection 2024 Jun.
To evaluate the associations between sleep quality and serum levels of neurofilament light (NfL) protein in individuals with premanifest Huntington disease (HD). We recruited 28 individuals with premanifest HD from a pre-existing database (of the Huntington's Environmental Research Optimisation Scheme, HEROs). The participants filled out the Pittsburgh Sleep Quality Index (PSQI), a subjective measure of sleep quality, and blood was collected via routine venepuncture to measure peripheral NfL levels. The PSQI scores (median: 5.0; interquartile range: 4.0-7.5) indicated poor sleep quality. General linear modelling revealed no significant ( = 0.242) association between PSQI scores and NfL levels. No significant differences were found between individuals with good and poor sleep quality for any demographic variable collected. Contrary to studies on other neurological conditions, there was no association between sleep quality and NfL levels in individuals with premanifest HD. This was unexpected, given the influence of environmental factors (such as social network size) on neurodegeneration in individuals with premanifest HD.
评估临床前期亨廷顿舞蹈症（HD）患者的睡眠质量与血清神经丝轻链（NfL）蛋白水平之间的关联。我们从一个现有的数据库（亨廷顿舞蹈症环境研究优化计划，HEROs）中招募了28名临床前期HD患者。参与者填写了匹兹堡睡眠质量指数（PSQI），这是一种对睡眠质量的主观测量方法，并通过常规静脉穿刺采血以测量外周血NfL水平。PSQI评分（中位数：5.0；四分位间距：4.0 - 7.5）表明睡眠质量较差。一般线性模型显示PSQI评分与NfL水平之间无显著关联（P = 0.242）。在收集的任何人口统计学变量方面，睡眠质量好与差的个体之间均未发现显著差异。与其他神经系统疾病的研究结果相反，临床前期HD患者的睡眠质量与NfL水平之间无关联。鉴于环境因素（如社交网络规模）对临床前期HD患者神经退行性变的影响，这一结果出乎意料。
