Suppr超能文献

神经旋毛虫病:系统文献回顾。

Neurotoxocariasis: a systematic literature review.

机构信息

Department of Internal Medicine, CHU de Caen, Caen, 14000, France.

Department of Microbiology, CHU de Caen, Caen, 14000, France.

出版信息

Infection. 2016 Oct;44(5):565-74. doi: 10.1007/s15010-016-0889-8. Epub 2016 Mar 23.

Abstract

PURPOSE

Toxocariasis is a widespread zoonosis, which may result in central nervous system injury.

METHODS

We conducted a systematic literature review in MEDLINE, SciELO, ScienceDirect and Google Scholar up to April 2015 using a combination of the following search terms: "neurotoxocariasis" or "neurotoxocarosis", "toxocariasis" or "toxocarosis" and "cerebral" or "neurologic".

RESULTS

One hundred cases of neurotoxocariasis were identified in literature. The majority of patients were male (58 %), with a median age of 42 years. The predominant clinical pictures were myelitis (60 %), encephalitis (47 %) and/or meningitis (29 %). Fever was inconstant (23 %). The suspected mode of transmission, mentioned in only 49 % of cases, was mainly contact with dogs and/or cats (67 %) and ingestion of contaminated food (31 %). Diagnostic imaging examinations found hypodense lesions in cerebral scanner sequences and hyperintense lesions in cerebral MRI T2-weighted sequences in 65 and 57 % of encephalitis cases respectively, and in 92 % of myelitis cases in medullary MRI T2-weighted sequences. The detection of antibodies against Toxocara spp. was almost constant in blood and cerebrospinal fluid (CSF), 99 and 93 %, respectively. The two most commonly used drugs were corticosteroids (72 %) and/or albendazole (68 %) for a period of at least 3 weeks, which often needed to be repeated. Despite a low mortality rate (6 %), complete remission was observed in only 40 % of cases.

CONCLUSIONS

Neurotoxocariasis, a completely preventable zoonosis, could lead to severe sequelae failing prompt diagnosis. A compatible clinical picture, presence of risk factors, blood eosinophilia and high titers of antibodies against Toxocara spp. in CSF should alert physicians.

摘要

目的

旋毛虫病是一种广泛存在的动物源性传染病,可能导致中枢神经系统损伤。

方法

我们在 MEDLINE、SciELO、ScienceDirect 和 Google Scholar 上进行了系统的文献综述,检索词组合包括“神经旋毛虫病”或“神经旋毛虫病”、“旋毛虫病”或“旋毛虫病”以及“大脑”或“神经病学”,检索时间截至 2015 年 4 月。

结果

文献中确定了 100 例神经旋毛虫病。大多数患者为男性(58%),中位年龄为 42 岁。主要的临床表现为脊髓炎(60%)、脑炎(47%)和/或脑膜炎(29%)。发热不常见(23%)。仅有 49%的病例提到了可疑的传播途径,主要是接触狗和/或猫(67%)和摄入受污染的食物(31%)。诊断性影像学检查发现脑扫描仪序列中的低信号病变和脑 MRI T2 加权序列中的高信号病变,脑炎病例分别为 65%和 57%,脊髓炎病例在髓质 MRI T2 加权序列中为 92%。血液和脑脊液(CSF)中抗旋毛虫属抗体的检测几乎是恒定的,分别为 99%和 93%。最常用的两种药物是皮质类固醇(72%)和/或阿苯达唑(68%),至少使用 3 周,往往需要重复使用。尽管死亡率较低(6%),但只有 40%的病例完全缓解。

结论

神经旋毛虫病是一种完全可以预防的动物源性传染病,如果不及时诊断,可能会导致严重的后遗症。存在临床症状、危险因素、血液嗜酸性粒细胞增多和 CSF 中抗旋毛虫属抗体高滴度,应引起医生警惕。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验