de Boysson Hubert, Martin Silva Nicolas, Comoz François, Boutemy Jonathan, Bienvenu Boris
Department of Internal Medicine, Caen University Hospital, Caen, France.
Service de Médecine Interne, CHU côte de Nacre, avenue de la côte de Nacre, BP 95182, 14033, Caen Cedex 9, France.
Infection. 2015 Dec;43(6):755-8. doi: 10.1007/s15010-015-0766-x. Epub 2015 Mar 26.
Vasculitides occurring during parasitic infection are rare and may imply different mechanisms.
A case report of cutaneous vasculitis and visceral damage during a larva migrans syndrome.
We report the case of a 64-year-old man who developed a purpura along with fever, respiratory failure, abdominal pain and myalgia. Immunological screening showed a high titer of both antinuclear antibodies and anti-double-stranded DNA antibodies along with anti-C1q antibodies. Toxocara canis serology returned highly positive with a positive western-blot. The use of antiparasitic drugs in combination with corticosteroids resulted in a dramatic improvement in the patient's condition.
Clinicians should be aware of the systemic complications that may occur during Toxocara canis infection, including vasculitis and immunological disorder.
寄生虫感染期间发生的血管炎很罕见，可能暗示不同的机制。
幼虫移行症综合征期间皮肤血管炎和内脏损害的病例报告。
我们报告了一名64岁男性的病例，他出现了紫癜，伴有发热、呼吸衰竭、腹痛和肌痛。免疫筛查显示抗核抗体和抗双链DNA抗体以及抗C1q抗体的高滴度。犬弓首线虫血清学检测呈高度阳性，免疫印迹法也呈阳性。使用抗寄生虫药物联合皮质类固醇导致患者病情显著改善。
临床医生应意识到犬弓首线虫感染期间可能发生的全身并发症，包括血管炎和免疫紊乱。
