Fang Na, Jiang Menglin, Fan Yu
Institute of Molecular Biology & Translational Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu 212002, PR China.
Institute of Molecular Biology & Translational Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu 212002, PR China.
Int J Cardiol. 2016 Jul 1;214:279-83. doi: 10.1016/j.ijcard.2016.03.210. Epub 2016 Apr 4.
Inconsistent findings have reported regarding ideal cardiovascular health metrics and cardiovascular disease (CVD) and mortality.
To investigate whether achieving a greater number of ideal cardiovascular health metrics was associated with a lower risk of CVD and mortality in the general population by conducting a meta-analysis of data from available prospective cohort studies.
A comprehensive literature search was conducted in PubMed, Embase, and Web of Science from their inception to February 2016. Only prospective cohort studies investigating the association between the ideal cardiovascular health metrics and CVD or mortality were eligible. The most-fully adjusted risk ratio (RR) and corresponding 95% confidence intervals (CI) was pooled to estimate the association.
Nine prospective cohort studies involving 12,878 participants were analyzed. Meta-analyses showed that achieving a greatest ideal cardiovascular health metrics was associated with lower risk of all-cause mortality (RR 0.55; 95% CI 0.37-0.80), cardiovascular mortality (RR 0.25; 95% CI 0.10-0.63), cardiovascular disease (RR 0.20; 95% CI 0.11-0.37),and stroke (RR 0.31; 95% CI 0.25-0.38).
Ideal cardiovascular health metrics are inversely associated with all-cause mortality and cardiovascular events, supporting the use of cardiovascular health metrics as a useful tool to predict mortality and cardiovascular disease risk.
关于理想的心血管健康指标与心血管疾病（CVD）及死亡率的研究结果并不一致。
通过对现有前瞻性队列研究的数据进行荟萃分析，调查在普通人群中实现更多理想心血管健康指标是否与较低的CVD风险和死亡率相关。
对PubMed、Embase和Web of Science从创刊至2016年2月进行全面的文献检索。只有调查理想心血管健康指标与CVD或死亡率之间关联的前瞻性队列研究符合条件。汇总调整最充分的风险比（RR）及相应的95%置信区间（CI）以估计这种关联。
分析了9项涉及12878名参与者的前瞻性队列研究。荟萃分析表明，实现更多理想心血管健康指标与全因死亡率风险降低（RR 0.55；95% CI 0.37 - 0.80）、心血管死亡率（RR 0.25；95% CI 0.10 - 0.63）、心血管疾病（RR 0.20；95% CI 0.11 - 0.37）和中风（RR 0.31；95% CI 0.25 - 0.38）相关。
理想的心血管健康指标与全因死亡率和心血管事件呈负相关，支持将心血管健康指标作为预测死亡率和心血管疾病风险的有用工具。
