F.C. Barcelona Medical Services, FIFA Medical Center of Excellence, Barcelona, Spain.
SM Genomics, Barcelona, Spain.
Knee Surg Sports Traumatol Arthrosc. 2017 Oct;25(10):3311-3318. doi: 10.1007/s00167-016-4081-6. Epub 2016 Apr 16.
Damage to skeletal muscle necessitates regeneration to maintain proper muscle form and function. Interindividual differences in injury severity, recovery time, and injury rate could be explained by the presence of single nucleotide polymorphisms (SNPs) in genes involved in the reparation and regeneration of connective tissue . We wished to identify new genetic biomarkers that could help to prevent or minimize the risk of non-contact muscle injuries and are associated with a predisposition to developing muscle injuries.
Using allelic discrimination techniques, we analysed 12 SNPs in selected genes from the genomic DNA of 74 elite soccer players.
SNPs in the hepatocyte growth factor (HGF) gene showed evidence of a statistically significant association with injury incidence, severity, and recovery time. SNPs in the SOX15 gene showed evidence of a statistically significant association with injury incidence. SNPs in the GEFT and LIF genes showed evidence of a statistically significant association with recovery time.
Genetic profile could explain why some elite soccer players are predisposed to suffer more injuries than others and why they need more time to recover from a particular injury. SNPs in HGF genes have an important role as biomarkers of biological processes fragility within muscle injuries related to injury rate, severity, and long recovery time.
骨骼肌损伤需要再生以维持适当的肌肉形态和功能。个体间损伤严重程度、恢复时间和损伤率的差异可以用参与结缔组织修复和再生的基因中的单核苷酸多态性（SNP）来解释。我们希望找到新的遗传生物标志物，以帮助预防或降低非接触性肌肉损伤的风险，并与肌肉损伤的易感性相关。
使用等位基因鉴别技术，我们分析了 74 名精英足球运动员基因组 DNA 中选定基因中的 12 个 SNP。
肝细胞生长因子（HGF）基因中的 SNP 与损伤发生率、严重程度和恢复时间有统计学显著关联的证据。SOX15 基因中的 SNP 与损伤发生率有统计学显著关联的证据。GEFT 和 LIF 基因中的 SNP 与恢复时间有统计学显著关联的证据。
遗传特征可以解释为什么一些精英足球运动员比其他人更容易受伤，以及为什么他们需要更多的时间从特定的损伤中恢复。HGF 基因中的 SNP 作为与损伤率、严重程度和恢复时间较长相关的肌肉损伤中生物过程脆弱性的生物标志物具有重要作用。
