Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8085, Japan.
Faculty of Health and Nutrition, Tokyo Seiei College, Tokyo 124-8530, Japan.
Genes (Basel). 2024 Jul 8;15(7):896. doi: 10.3390/genes15070896.
This study sought to assess how post-game creatine kinase (CK) levels correlate with the number of sprints and the impact of the polymorphism on this response. This research constituted a descriptive/observational, retrospective cross-sectional study. DNA was extracted from blood samples for polymorphism genotyping. CK was measured 48 h after official matches, and the number of sprints (>19 km/h) was tracked using Global Positioning System (GPS) technology. The main cohort included 23 professional soccer players from the top tier of the Brazilian Championship. We analyzed 115 GPS + CK data sets. The replication cohort comprised 18 professional soccer players from the First Division of the Championship, had the same methodology applied, and featured a total of 90 GPS (sprints > 25.2 km/h) + CK data sets. For the main cohort, a significant positive correlation was seen between the number of sprints and the CK levels ( = 0.009). Athletes with the RR genotype had higher CK levels as more sprints were performed during the match ( = 0.017). However, the relationship was not found for X allele carriers ( > 0.05). For the replication cohort, there was a near-significant correlation between CK levels and the number of sprints ( = 0.05), and RR individuals showed a significant association ( = 0.01), whereas X allele carriers did not ( = 0.06). A greater number of sprints during matches is linked to higher CK levels, primarily among players with the RR genotype, which is potentially due to an increased presence of type II muscle fibers. These findings were replicated for both cohorts of elite Brazilian soccer players, emphasizing the importance of genetic factors in injury prevention.
本研究旨在评估赛后肌酸激酶（CK）水平与冲刺次数的相关性，以及该多态性对这一反应的影响。本研究为描述性/观察性、回顾性横断面研究。从血样中提取 DNA 进行多态性基因分型。在官方比赛后 48 小时测量 CK，使用全球定位系统（GPS）技术跟踪冲刺次数（>19km/h）。主要队列包括巴西锦标赛顶级联赛的 23 名职业足球运动员。我们分析了 115 个 GPS+CK 数据集。复制队列由锦标赛甲级的 18 名职业足球运动员组成，应用相同的方法，共包含 90 个 GPS（冲刺>25.2km/h）+CK 数据集。对于主要队列，冲刺次数与 CK 水平之间存在显著正相关（=0.009）。在比赛中进行更多冲刺时，RR 基因型运动员的 CK 水平更高（=0.017）。然而，对于 X 等位基因携带者，这种关系并不存在（>0.05）。对于复制队列，CK 水平与冲刺次数之间存在近显著相关性（=0.05），RR 个体表现出显著相关性（=0.01），而 X 等位基因携带者则没有（=0.06）。比赛中冲刺次数越多，CK 水平越高，主要是在 RR 基因型的运动员中，这可能是由于 II 型肌纤维的存在增加所致。这些发现得到了巴西精英足球运动员两个队列的复制，强调了遗传因素在预防损伤方面的重要性。
