Russell A E, Cain M D, Kapoor V, Morris M J, Chalmers J P
Department of Medicine, Flinders Medical Centre, Adelaide, South Australia.
J Auton Nerv Syst. 1989 Feb;26(1):85-8. doi: 10.1016/0165-1838(89)90111-2.
Previous studies have demonstrated that plasma Neuropeptide Y-like immunoreactivity (NPY-LI) increases after activation of sympathetic nerves. To test the hypothesis that the adrenal medulla may also be a significant source of circulating plasma NPY-LI and to determine if NPY is co-released with adrenal catecholamines, we have measured the peripheral venous concentrations of NPY-LI, adrenaline and noradrenaline in six patients, before and after induction of hypoglycaemia as part of pituitary function tests that also tested gonadotrophin and thyroid stimulating hormone release. The plasma adrenaline concentration was increased approximately 15 times (p less than 0.05) relative to baseline at 30 mins and remained elevated for the 90 minutes of the study. The plasma concentration of both noradrenaline and NPY-LI remained unchanged. These results failed to demonstrate an increase in the amount of NPY-LI released into the plasma during stimulation of the adrenal medulla with hypoglycaemic stress in man. They do not support significant co-release of NPY with adrenaline from the adrenal medulla in man, nor a physiological role for NPY as an adrenal hormone in human subjects in this situation.
先前的研究表明，交感神经激活后血浆中神经肽Y样免疫反应性物质（NPY-LI）会增加。为了验证肾上腺髓质可能也是循环血浆中NPY-LI的重要来源这一假说，并确定NPY是否与肾上腺儿茶酚胺共同释放，我们测量了6例患者在低血糖诱导前后外周静脉血中NPY-LI、肾上腺素和去甲肾上腺素的浓度，低血糖诱导是垂体功能测试的一部分，该测试还检测了促性腺激素和促甲状腺激素的释放。在30分钟时，血浆肾上腺素浓度相对于基线水平增加了约15倍（p<0.05），并在研究的90分钟内一直保持升高。去甲肾上腺素和NPY-LI的血浆浓度均保持不变。这些结果未能证明在人体因低血糖应激刺激肾上腺髓质期间，释放到血浆中的NPY-LI量有所增加。它们不支持在人体中NPY与肾上腺素从肾上腺髓质共同大量释放，也不支持在这种情况下NPY作为肾上腺激素在人体中的生理作用。
