Kim Young-Nam, Hwang Ji Hyeon, Cho Youn-Ok
Department of Food and Nutrition, Duksung Women's University, 33 Samyangro 144-gil, Dong-gu, Seoul 01369, Korea.
Nutr Res Pract. 2016 Apr;10(2):161-6. doi: 10.4162/nrp.2016.10.2.161. Epub 2016 Feb 26.
BACKGROUND/OBJECTIVES: Energy production and the rebuilding and repair of muscle tissue by physical activity require folate and vitamin B12 as a cofactor. Thus, this study investigated the effects of regular moderate exercise training and durations of acute aerobic exercise on plasma folate and vitamin B12 concentrations in moderate exercise trained rats.
MATERIALS/METHODS: Fifty rats underwent non-exercise training (NT, n = 25) and regular exercise training (ET, n = 25) for 5 weeks. The ET group performed moderate exercise on a treadmill for 30 min/day, 5 days/week. At the end of week 5, each group was subdivided into 4 groups: non-exercise and 3 exercise groups. The non-exercise group (E0) was sacrificed without exercising and the 3 exercise groups were sacrificed immediately after exercising on a treadmill for 0.5 h (E0.5), 1 h (E1), and 2 h (E2). Blood samples were collected and plasma folate and vitamin B12 were analyzed.
After exercise training, plasma folate level was significantly lower and vitamin B12 concentration was significantly higher in the ET group compared with the NT group (P < 0.05). No significant associations were observed between plasma folate and vitamin B12 concentrations. In both the NT and ET groups, plasma folate and vitamin B12 were not significantly changed by increasing duration of aerobic exercise. Plasma folate concentration of E0.5 was significantly lower in the ET group compared with that in the NT group. Significantly higher vitamin B12 concentrations were observed in the E0 and E0.5 groups of the ET group compared to those of the NT group.
Regular moderate exercise training decreased plasma folate and increased plasma vitamin B12 levels. However, no significant changes in plasma folate and vitamin B12 concentrations were observed by increasing duration of acute aerobic exercise.
背景/目的：能量产生以及通过体育活动对肌肉组织进行重建和修复需要叶酸和维生素B12作为辅助因子。因此，本研究调查了定期适度运动训练以及急性有氧运动持续时间对适度运动训练大鼠血浆叶酸和维生素B12浓度的影响。
材料/方法：50只大鼠接受了5周的非运动训练（NT，n = 25）和定期运动训练（ET，n = 25）。ET组每天在跑步机上进行30分钟的适度运动，每周5天。在第5周结束时，每组再分为4组：非运动组和3个运动组。非运动组（E0）不运动直接处死，3个运动组在跑步机上运动0.5小时（E0.5）、1小时（E1）和2小时（E2）后立即处死。采集血样并分析血浆叶酸和维生素B12。
运动训练后，与NT组相比，ET组的血浆叶酸水平显著降低，维生素B12浓度显著升高（P < 0.05）。未观察到血浆叶酸和维生素B12浓度之间存在显著关联。在NT组和ET组中，有氧运动持续时间增加并未使血浆叶酸和维生素B12发生显著变化。与NT组相比，ET组中E0.5的血浆叶酸浓度显著降低。与NT组相比，ET组的E0和E0.5组中维生素B12浓度显著更高。
定期适度运动训练可降低血浆叶酸水平并提高血浆维生素B12水平。然而，急性有氧运动持续时间增加并未使血浆叶酸和维生素B12浓度发生显著变化。
