铜催化的对醌甲基化物的硼氢化芳构化反应：二苄基硼酸酯的对映选择性合成
Copper-Catalyzed Borylative Aromatization of -Quinone Methides: Enantioselective Synthesis of Dibenzylic Boronates.
作者信息
Jarava-Barrera Carlos, Parra Alejandro, López Aurora, Cruz-Acosta Fabio, Collado-Sanz Daniel, Cárdenas Diego J, Tortosa Mariola
机构信息
Departamento de Química Orgánica, Universidad Autónoma de Madrid , Cantoblanco, 28049 Madrid, Spain.
出版信息
ACS Catal. 2016 Jan 4;6(1):442-446. doi: 10.1021/acscatal.5b02742. Epub 2015 Dec 11.
In this report, we establish that DM-Segphos copper(I) complexes are efficient catalysts for the enantioselective borylation of -quinone methides. This method provides straightforward access to chiral monobenzylic and dibenzylic boronic esters, with enantiomeric ratios up to 96:4, using a commercially available chiral phosphine. Standard manipulations of the C-B bond afford a variety of chiral diaryl derivatives.
在本报告中，我们证实了DM-Segphos铜（I）配合物是对醌甲基化物对映选择性硼氢化反应的有效催化剂。该方法使用市售手性膦，可直接得到对映体比例高达96:4的手性单苄基硼酸酯和二苄基硼酸酯。C-B键的常规操作可得到多种手性二芳基衍生物。
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