Telford D R, Morris J A, Hughes P, Conway A R, Lee S, Barson A J, Drucker D B
Lancaster Moor Hospital, U.K.
J Infect. 1989 Mar;18(2):125-30. doi: 10.1016/s0163-4453(89)91094-3.
The nasopharyngeal bacterial flora in babies who had died of the sudden infant death syndrome (SIDS) (n = 46) and in healthy infants aged 2 weeks to 6 months (n = 46) is described. Of those who had died, 41.3% carried Staphylococcus aureus (95% confidence limits: 27.3-55.3%) compared with 28.3% of healthy infants (95% confidence limits: 15.3-41.3%). The isolation rate of streptococci was 78.3% in cases (95% confidence limits: 66.4-90.2%) and 32.6% in healthy infants (95% confidence limits: 19.1-46.1%) (significant difference P less than 0.0001). Enterobacteria were isolated from 45.6% of cases (95% confidence limits: 31.2-60%) but only 2.2% of healthy infants (95% confidence limits 0-6.4%) (significant difference, P less than 0.0001). These results indicate a disordered nasopharyngeal flora in SIDS. They also provide baseline data for investigating the hypothesis that common bacterial toxins are involved in the pathogenesis of SIDS.
本文描述了死于婴儿猝死综合征（SIDS）的婴儿（n = 46）和2周龄至6个月的健康婴儿（n = 46）的鼻咽部细菌菌群。在死亡婴儿中，41.3%携带金黄色葡萄球菌（95%置信区间：27.3 - 55.3%），而健康婴儿中这一比例为28.3%（95%置信区间：15.3 - 41.3%）。病例组链球菌分离率为78.3%（95%置信区间：66.4 - 90.2%），健康婴儿组为32.6%（95%置信区间：19.1 - 46.1%）（P < 0.0001，差异有统计学意义）。45.6%的病例组分离出肠杆菌（95%置信区间：31.2 - 60%），而健康婴儿组仅为2.2%（95%置信区间：0 - 6.4%）（P < 0.0001，差异有统计学意义）。这些结果表明SIDS患儿存在鼻咽部菌群紊乱。它们还为研究常见细菌毒素参与SIDS发病机制这一假说提供了基线数据。
