Lee S, Barson A J, Drucker D B, Morris J A, Telford D R
Department of Pathology, Medical School, Manchester.
J Clin Pathol. 1987 Dec;40(12):1393-6. doi: 10.1136/jcp.40.12.1393.
An attempt was made to produce an animal model of sudden infant death syndrome (SIDS). The experimental animals (germ free weanling rats) were exposed to nasopharyngeal isolates from cases of SIDS to test the hypothesis that common bacteria may have an aetiological role in the disease. Negative results were obtained when the strains were tested in isolation, but certain combinations of organisms (specifically some Staphylococcus aureus and Escherichia coli) killed the animals rapidly (less than 18 hours) without prolonged terminal illness. Post mortem histological findings were consistent with those of SIDS. The lethal toxigenic potential of nasopharyngeal bacteria, which are regarded as harmless in adults, should be reconsidered in respect of the aetiology of SIDS.
曾尝试制作婴儿猝死综合征（SIDS）的动物模型。实验动物（无菌断奶大鼠）接触了来自SIDS病例的鼻咽分离株，以检验常见细菌可能在该疾病中起病因学作用这一假设。当单独测试这些菌株时，得到了阴性结果，但某些生物体的组合（特别是一些金黄色葡萄球菌和大肠杆菌）能迅速（不到18小时）杀死动物，且没有长期的末期疾病。尸检组织学结果与SIDS的结果一致。对于SIDS的病因学，应重新考虑在成年人中被视为无害的鼻咽部细菌的潜在致命产毒能力。
