Immunobiology Laboratory, The Francis Crick Institute, Lincoln's Inn Fields Laboratory, London, UK.
MRC Laboratory of Molecular and Cellular Biology, University College London, London, UK.
Immunol Rev. 2016 May;271(1):221-9. doi: 10.1111/imr.12414.
A critical hallmark of adaptive immune responses is the rapid and extensive expansion of lymph nodes. During this process, the complex internal structure of the organs is maintained revealing the existence of mechanisms able to balance lymph node integrity with structural flexibility. This article reviews the extensive architectural remodeling that occurs within lymph nodes during adaptive immune responses and how it is regulated by dendritic cells (DCs). In particular we focus on previously unappreciated functions of DCs in coordinating remodeling of lymph node vasculature, expansion of the fibroblastic reticular network and maintenance of lymphoid stromal phenotypes. Our increased understanding of these processes indicates that DCs need to be viewed not only as key antigen-presenting cells for lymphocytes but also as broad-acting immune sentinels that convey signals to lymphoid organ stroma and thereby facilitate immune response initiation at multiple levels.
适应性免疫反应的一个关键标志是淋巴结的快速和广泛扩张。在这个过程中，器官的复杂内部结构得以维持，这表明存在着能够平衡淋巴结完整性与结构灵活性的机制。本文综述了适应性免疫反应过程中淋巴结内发生的广泛的结构重塑，以及树突状细胞（DC）如何调节这种重塑。我们特别关注 DC 在协调淋巴结脉管系统重塑、纤维母细胞网状网络扩张和淋巴样基质表型维持方面的以前未被认识到的功能。我们对这些过程的认识的提高表明，不仅需要将 DC 视为淋巴细胞的关键抗原呈递细胞，还需要将其视为广泛作用的免疫哨兵，向淋巴器官基质传递信号，从而在多个层面上促进免疫反应的启动。
