Dadjou Yahya, Kermani-Alghoraishi Mohammad, Sadeghi Masoumeh, Talaei Mohammad, Yousefy Alireza, Oveisgharan Shahram, Roohafza Hamidreza, Rabiei Katayoun, Sarrafzadegan Nizal
Acta Cardiol. 2016 Apr;71(2):221-6. doi: 10.2143/AC.71.2.3141853.
The aim of study was to evaluate the impact of health-related quality of life (QoL) on the occurrence of ischaemic heart disease (IHD) and stroke using a validated questionnaire.
We followed the 3,283 subjects, aged ≥ 35 years and without history of cardiovascular events (CVE) over four years from 2007 to 2011 from the Isfahan cohort study. The World Health Organization QoL questionnaire (WHOQOL-BREF), which contains four separate domains, was used to assess QoL. Incidence rates of IHD and stroke were recorded during follow-up. Socioeconomic demographic data including marital state, educational level, occupation, income and place of living and metabolic risk factors such as diabetes mellitus (DM), hypertension (HTN), dyslipidaemia, body mass index and smoking were also recorded.
More IHD (42%) and stroke (57%) patients were illiterate; while the educational status was significantly different only in the IHD group (P = 0.000). Differences in income and occupation were notable in patients with stroke and IHD, respectively, compared to subjects without them (P < 0.050). DM and HTN were significantly higher in IHD and stroke patients in comparison with subjects without CVE (P = 0.000). Two-way multivariate analyses of covariance test after age, educational status and metabolic risk factors adjustment showed that subjects with stroke had a significantly higher score in all QoL domains in comparison with individuals without stroke (P < 0.050). There was no significant association between QoL domains and IHD incidence (P > 0.050).
This study indicates that there is no association between QoL and IHD incidence although there was a significant relationship between higher QoL and incidence of stroke.
本研究旨在使用经过验证的问卷评估健康相关生活质量（QoL）对缺血性心脏病（IHD）和中风发生的影响。
我们对来自伊斯法罕队列研究的3283名年龄≥35岁且无心血管事件（CVE）病史的受试者进行了为期四年的随访，时间从2007年至2011年。使用包含四个独立领域的世界卫生组织生活质量问卷（WHOQOL-BREF）来评估生活质量。在随访期间记录IHD和中风的发病率。还记录了社会经济人口统计学数据，包括婚姻状况、教育水平、职业、收入和居住地点，以及代谢危险因素，如糖尿病（DM）、高血压（HTN）、血脂异常、体重指数和吸烟情况。
更多的IHD患者（42%）和中风患者（57%）是文盲；而教育状况仅在IHD组中有显著差异（P = 0.000）。与没有中风和IHD的受试者相比，中风患者和IHD患者的收入和职业差异分别显著（P < 0.050）。与没有CVE的受试者相比，IHD和中风患者的DM和HTN显著更高（P = 0.000）。在对年龄、教育状况和代谢危险因素进行调整后，双向多变量协方差分析表明，与没有中风的个体相比，中风患者在所有生活质量领域的得分显著更高（P < 0.050）。生活质量领域与IHD发病率之间没有显著关联（P > 0.050）。
本研究表明，生活质量与IHD发病率之间没有关联，尽管较高的生活质量与中风发病率之间存在显著关系。
